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Literature DB >> 24097272

VEGFA rSNPs, transcriptional factor binding sites and human disease.

Abstract

Three regulatory SNPs (rSNPs) in the promoter region of the vascular endothelial growth factor-A (VEGFA) gene have been significantly associated with several human diseases or conditions. The rSNP alleles alter the DNA landscape for potential transcriptional factors to attach, resulting in changes in transcriptional factor binding sites (TFBS). These TFBS changes are examined with respect to the human diseases which have been found to be significantly associated with the rSNPs.

Entities: Gene Species

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Substances：

Year: 2013 PMID： 24097272 DOI： 10.1007/s12576-013-0293-4

Source DB: PubMed Journal: J Physiol Sci ISSN： 1880-6546 Impact factor: 2.781

36 in total

1. JASPAR: an open-access database for eukaryotic transcription factor binding profiles.

Authors: Albin Sandelin; Wynand Alkema; Pär Engström; Wyeth W Wasserman; Boris Lenhard
Journal: Nucleic Acids Res Date: 2004-01-01 Impact factor: 16.971

2. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

Authors: Lucia A Hindorff; Praveen Sethupathy; Heather A Junkins; Erin M Ramos; Jayashri P Mehta; Francis S Collins; Teri A Manolio
Journal: Proc Natl Acad Sci U S A Date: 2009-05-27 Impact factor: 11.205

3. Genetic polymorphisms in oestrogen receptor-binding sites affect clinical outcomes in patients with prostate cancer receiving androgen-deprivation therapy.

Authors: C-N Huang; S-P Huang; J-B Pao; T-C Hour; T-Y Chang; Y-H Lan; T-L Lu; H-Z Lee; S-H Juang; P-P Wu; C-Y Huang; C-J Hsieh; B-Y Bao
Journal: J Intern Med Date: 2011-09-29 Impact factor: 8.989

4. The Biology of Genomes. Disease risk links to gene regulation.

Authors: Elizabeth Pennisi
Journal: Science Date: 2011-05-27 Impact factor: 47.728

5. A functional variant of vascular endothelial growth factor is associated with severe ischemic complications in giant cell arteritis.

Authors: Blanca Rueda; Miguel A Lopez-Nevot; Maria J Lopez-Diaz; Carlos Garcia-Porrua; Javier Martín; Miguel A Gonzalez-Gay
Journal: J Rheumatol Date: 2005-09 Impact factor: 4.666

6. Identification of polymorphic antioxidant response elements in the human genome.

Authors: Xuting Wang; Daniel J Tomso; Brian N Chorley; Hye-Youn Cho; Vivian G Cheung; Steven R Kleeberger; Douglas A Bell
Journal: Hum Mol Genet Date: 2007-04-04 Impact factor: 6.150

Review 7. Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation.

Authors: F Claessens; G Verrijdt; E Schoenmakers; A Haelens; B Peeters; G Verhoeven; W Rombauts
Journal: J Steroid Biochem Mol Biol Date: 2001 Jan-Mar Impact factor: 4.292

8. Tissue- and cell-specific alternative splicing of NFIC.

Authors: Ejvis Lamani; Yixin Wu; Juan Dong; Mark Stephen Litaker; Ana Carolina Acevedo; Mary MacDougall
Journal: Cells Tissues Organs Date: 2008-09-01 Impact factor: 2.481

9. AP1 binding site is another target of FGF2 regulation of bone sialoprotein gene transcription.

Authors: Hideki Takai; Shouta Araki; Masaru Mezawa; Dong-Soon Kim; Xinyue Li; Li Yang; Zhengyang Li; Zhitao Wang; Youhei Nakayama; Yorimasa Ogata
Journal: Gene Date: 2007-12-07 Impact factor: 3.688

Review 10. From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases.

Authors: Vinod Kumar; Cisca Wijmenga; Sebo Withoff
Journal: Semin Immunopathol Date: 2012-05-14 Impact factor: 9.623

3 in total