OBJECTIVE: To investigate whether occupational exposure to polycyclic aromatic hydrocarbons and certain plastic monomers increased renal cell carcinoma (RCC) risk. METHODS: Unconditional logistic regression was used to calculate RCC risk in relation to exposure. RESULTS: No association between RCC risk and having ever been occupationally exposed to any polycyclic aromatic hydrocarbons or plastics was observed. Duration of exposure and average exposure also showed no association with risk. Suggestive positive associations between RCC risk and cumulative exposure to styrene (P-trend = 0.02) and acrylonitrile (P-trend = 0.06) were found. Cumulative exposure to petroleum/gasoline engine emissions was inversely associated with risk (P-trend = 0.02). CONCLUSIONS: Results indicate a possible association between occupational styrene and acrylonitrile exposure and RCC risk. Additional studies are needed to replicate findings, as this is the first time these associations have been reported and they may be due to chance.
OBJECTIVE: To investigate whether occupational exposure to polycyclic aromatic hydrocarbons and certain plastic monomers increased renal cell carcinoma (RCC) risk. METHODS: Unconditional logistic regression was used to calculate RCC risk in relation to exposure. RESULTS: No association between RCC risk and having ever been occupationally exposed to any polycyclic aromatic hydrocarbons or plastics was observed. Duration of exposure and average exposure also showed no association with risk. Suggestive positive associations between RCC risk and cumulative exposure to styrene (P-trend = 0.02) and acrylonitrile (P-trend = 0.06) were found. Cumulative exposure to petroleum/gasoline engine emissions was inversely associated with risk (P-trend = 0.02). CONCLUSIONS: Results indicate a possible association between occupational styrene and acrylonitrile exposure and RCC risk. Additional studies are needed to replicate findings, as this is the first time these associations have been reported and they may be due to chance.
Authors: Gerard M H Swaen; Louis J N Bloemen; Jan Twisk; Theo Scheffers; Jos J M Slangen; James J Collins; Wil F J P ten Berge Journal: J Occup Environ Med Date: 2004-07 Impact factor: 2.162
Authors: Lee E Moore; Paolo Boffetta; Sara Karami; Paul Brennan; Patricia S Stewart; Rayjean Hung; David Zaridze; Vsevolod Matveev; Vladimir Janout; Helena Kollarova; Vladimir Bencko; Marie Navratilova; Neonila Szeszenia-Dabrowska; Dana Mates; Jan Gromiec; Ivana Holcatova; Maria Merino; Stephen Chanock; Wong-Ho Chow; Nathaniel Rothman Journal: Cancer Res Date: 2010-07-27 Impact factor: 12.701
Authors: Deepika Shrestha; Sa Liu; S Katharine Hammond; Michael P LaValley; Daniel E Weiner; Ellen A Eisen; Katie M Applebaum Journal: Occup Environ Med Date: 2016-08-02 Impact factor: 4.402