Literature DB >> 21258614

DESIGN AND PRELIMINARY VALIDATION OF A RAPID AUTOMATED BIODOSIMETRY TOOL FOR HIGH THROUGPUT RADIOLOGICAL TRIAGE.

Youhua Chen1, Jian Zhang, Hongliang Wang, Guy Garty, Yanping Xu, Oleksandra V Lyulko, Helen C Turner, Gerhard Randers-Pehrson, Nabil Simaan, Y Lawrence Yao, D J Brenner.   

Abstract

This paper presents design, hardware, software, and parameter optimization for a novel robotic automation system. RABiT is a Rapid Automated Biodosimetry Tool for high throughput radiological triage. The design considerations guiding the hardware and software architecture are presented with focus on methods of communication, ease of implementation, and need for real-time control versus soft time control cycles. The design and parameter determination for a non-contact PVC capillary laser cutting system is presented. A novel approach for lymphocyte concentration estimation based on computer vision is reported. Experimental evaluations of the system components validate the success of our prototype system in achieving a throughput of 6,000 samples in a period of 18 hours.

Entities:  

Year:  2009        PMID： 21258614      PMCID： PMC3024000          DOI： 10.1115/DETC2009-86425

Source DB:  PubMed          Journal:  Proc ASME Des Eng Tech Conf


  5 in total

Review 1.  Priority list of research areas for radiological nuclear threat countermeasures.

Authors:  Terry C Pellmar; Sara Rockwell
Journal:  Radiat Res       Date:  2005-01       Impact factor: 2.841

2.  An ontology for a Robot Scientist.

Authors:  Larisa N Soldatova; Amanda Clare; Andrew Sparkes; Ross D King
Journal:  Bioinformatics       Date:  2006-07-15       Impact factor: 6.937

3.  Techniques for gamma-H2AX detection.

Authors:  Asako Nakamura; Olga A Sedelnikova; Christophe Redon; Duane R Pilch; Natasha I Sinogeeva; Robert Shroff; Michael Lichten; William M Bonner
Journal:  Methods Enzymol       Date:  2006       Impact factor: 1.600

4.  HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures.

Authors:  M Fenech; W P Chang; M Kirsch-Volders; N Holland; S Bonassi; E Zeiger
Journal:  Mutat Res       Date:  2003-01-10       Impact factor: 2.433

5.  High-throughput isolation of ultra-pure plasmid DNA by a robotic system.

Authors:  Volker Kachel; Georg Sindelar; Stefan Grimm
Journal:  BMC Biotechnol       Date:  2006-02-16       Impact factor: 2.563
  5 in total
  6 in total

1.  An automated imaging system for radiation biodosimetry.

Authors:  Guy Garty; Alan W Bigelow; Mikhail Repin; Helen C Turner; Dakai Bian; Adayabalam S Balajee; Oleksandra V Lyulko; Maria Taveras; Y Lawrence Yao; David J Brenner
Journal:  Microsc Res Tech       Date:  2015-05-04       Impact factor: 2.769

2.  THE DECADE OF THE RABiT (2005-15).

Authors:  G Garty; H C Turner; A Salerno; A Bertucci; J Zhang; Y Chen; A Dutta; P Sharma; D Bian; M Taveras; H Wang; A Bhatla; A Balajee; A W Bigelow; M Repin; O V Lyulko; N Simaan; Y L Yao; D J Brenner
Journal:  Radiat Prot Dosimetry       Date:  2016-07-13       Impact factor: 0.972

3.  The RABiT: a rapid automated biodosimetry tool for radiological triage. II. Technological developments.

Authors:  Guy Garty; Youhua Chen; Helen C Turner; Jian Zhang; Oleksandra V Lyulko; Antonella Bertucci; Yanping Xu; Hongliang Wang; Nabil Simaan; Gerhard Randers-Pehrson; Y Lawrence Yao; David J Brenner
Journal:  Int J Radiat Biol       Date:  2011-05-11       Impact factor: 2.694

4.  Adapting the γ-H2AX assay for automated processing in human lymphocytes. 1. Technological aspects.

Authors:  Helen C Turner; David J Brenner; Youhua Chen; Antonella Bertucci; Jian Zhang; Hongliang Wang; Oleksandra V Lyulko; Yanping Xu; Igor Shuryak; Julia Schaefer; Nabil Simaan; Gerhard Randers-Pehrson; Y Lawrence Yao; Sally A Amundson; Guy Garty
Journal:  Radiat Res       Date:  2010-12-28       Impact factor: 2.841

5.  The RABiT: high-throughput technology for assessing global DSB repair.

Authors:  Helen C Turner; P Sharma; J R Perrier; A Bertucci; L Smilenov; G Johnson; M Taveras; D J Brenner; G Garty
Journal:  Radiat Environ Biophys       Date:  2014-01-30       Impact factor: 1.925

6.  High throughput measurement of γH2AX DSB repair kinetics in a healthy human population.

Authors:  Preety M Sharma; Brian Ponnaiya; Maria Taveras; Igor Shuryak; Helen Turner; David J Brenner
Journal:  PLoS One       Date:  2015-03-20       Impact factor: 3.240
  6 in total

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