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Literature DB >> 21190058

Technologies of directed protein evolution in vivo.

Artem Blagodatski¹, Vladimir L Katanaev.

Abstract

Directed evolution of proteins for improved or modified functionality is an important branch of modern biotechnology. It has traditionally been performed using various in vitro methods, but more recently, methods of in vivo artificial evolution come into play. In this review, we discuss and compare prokaryotic and eukaryotic-based systems of directed protein evolution in vivo, highlighting their benefits and current limitations and focusing on the biotechnological potential of vertebrate immune cells for the generation of protein diversity by means of the immunoglobulin diversification machinery.

Mesh：

Substances：
Proteins

Year: 2010 PMID： 21190058 DOI： 10.1007/s00018-010-0610-5

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

65 in total

Review 1. Immunity through DNA deamination.

Authors: Michael S Neuberger; Reuben S Harris; Javier Di Noia; Svend K Petersen-Mahrt
Journal: Trends Biochem Sci Date: 2003-06 Impact factor: 13.807

Review 2. PCR approaches to DNA mutagenesis and recombination. An overview.

Authors: Binzhang Shen
Journal: Methods Mol Biol Date: 2002

Review 3. In-vitro protein evolution by ribosome display and mRNA display.

Authors: Dasa Lipovsek; Andreas Plückthun
Journal: J Immunol Methods Date: 2004-07 Impact factor: 2.303

Review 4. Protein design by directed evolution.

Authors: Christian Jäckel; Peter Kast; Donald Hilvert
Journal: Annu Rev Biophys Date: 2008 Impact factor: 12.981

Review 5. An efficient random mutagenesis technique using an E. coli mutator strain.

Authors: A Greener; M Callahan; B Jerpseth
Journal: Methods Mol Biol Date: 1996

6. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line.

Authors: J E Sale; M S Neuberger
Journal: Immunity Date: 1998-12 Impact factor: 31.745

Review 7. Protein engineering of microbial enzymes.

Authors: Dominique Böttcher; Uwe T Bornscheuer
Journal: Curr Opin Microbiol Date: 2010-02-17 Impact factor: 7.934

8. Rapid generation of specific antibodies by enhanced homologous recombination.

Authors: Hidetaka Seo; Mieko Masuoka; Hiromu Murofushi; Shunichi Takeda; Takehiko Shibata; Kunihiro Ohta
Journal: Nat Biotechnol Date: 2005-05-29 Impact factor: 54.908

Review 9. Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.

Authors: Hiroshi Arakawa; Jean-Marie Buerstedde
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2009-03-12 Impact factor: 6.237

10. Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell line.

Authors: Naoki Kanayama; Kagefumi Todo; Satoko Takahashi; Masaki Magari; Hitoshi Ohmori
Journal: Nucleic Acids Res Date: 2006-01-18 Impact factor: 16.971

5 in total

1. Directed evolution of mammalian anti-apoptosis proteins by somatic hypermutation.

Authors: Brian S Majors; Gisela G Chiang; Nels E Pederson; Michael J Betenbaugh
Journal: Protein Eng Des Sel Date: 2011-12-09 Impact factor: 1.650

Review 2. Genetically modified proteins: functional improvement and chimeragenesis.

Authors: Larissa Balabanova; Vasily Golotin; Anna Podvolotskaya; Valery Rasskazov
Journal: Bioengineered Date: 2015-07-25 Impact factor: 3.269

3. Identification of human butyrylcholinesterase organophosphate-resistant variants through a novel mammalian enzyme functional screen.

Authors: Jun Zhang; Sigeng Chen; Erik C Ralph; Mary Dwyer; John R Cashman
Journal: J Pharmacol Exp Ther Date: 2012-09-06 Impact factor: 4.030

Review 4. Optimization of enzyme parameters for fermentative production of biorenewable fuels and chemicals.

Authors: Laura R Jarboe; Ping Liu; Kumar Babu Kautharapu; Lonnie O Ingram
Journal: Comput Struct Biotechnol J Date: 2012-10-31 Impact factor: 7.271

Review 5. Targeting the Wnt pathways for therapies.

Authors: Artem Blagodatski; Dmitry Poteryaev; Vladimir L Katanaev
Journal: Mol Cell Ther Date: 2014-09-11

5 in total