OBJECTIVE: We wanted to explore if FTO genotype interacts with fat intake, or leisure-time physical activity, on fat mass, lean mass and mortality. SUBJECTS AND METHODS: Among 22,799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up. Leisure-time physical activity was determined from a list of 17 different physical activities in a questionnaire. Body composition was measured using bioelectric impedance method. RESULTS: FTO genotype associated strongly with both fat mass and lean mass (P(trend) <1 × 10(-16) for both) but we found only significant interactions with fat intake, or physical activity, on fat mass (P(interaction)=0.01 and 0.004). No significant interaction between FTO genotype and fat intake (P(interaction)=0.72), or leisure-time physical activity (P(interaction)=0.07), on total mortality were observed. However, we observed a significant interaction between leisure-time physical activity and FTO genotype on cardiovascular mortality (P(interaction)=0.03). The highest vs lowest quintile of physical activity was associated with 46% (95% confidence interval, 17-64%) reduced cardiovascular mortality among TT-carriers (P(trend)=0.004), and 11% reduced cardiovascular mortality among A-allele carriers (P(trend)=0.68). CONCLUSION: Our results indicate that FTO genotype associates with both fat mass and lean mass, but the level of fat intake and physical activity only modify the association with fat mass. In addition, FTO genotype may modify the association between physical activity and cardiovascular mortality.
OBJECTIVE: We wanted to explore if FTO genotype interacts with fat intake, or leisure-time physical activity, on fat mass, lean mass and mortality. SUBJECTS AND METHODS: Among 22,799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up. Leisure-time physical activity was determined from a list of 17 different physical activities in a questionnaire. Body composition was measured using bioelectric impedance method. RESULTS:FTO genotype associated strongly with both fat mass and lean mass (P(trend) <1 × 10(-16) for both) but we found only significant interactions with fat intake, or physical activity, on fat mass (P(interaction)=0.01 and 0.004). No significant interaction between FTO genotype and fat intake (P(interaction)=0.72), or leisure-time physical activity (P(interaction)=0.07), on total mortality were observed. However, we observed a significant interaction between leisure-time physical activity and FTO genotype on cardiovascular mortality (P(interaction)=0.03). The highest vs lowest quintile of physical activity was associated with 46% (95% confidence interval, 17-64%) reduced cardiovascular mortality among TT-carriers (P(trend)=0.004), and 11% reduced cardiovascular mortality among A-allele carriers (P(trend)=0.68). CONCLUSION: Our results indicate that FTO genotype associates with both fat mass and lean mass, but the level of fat intake and physical activity only modify the association with fat mass. In addition, FTO genotype may modify the association between physical activity and cardiovascular mortality.
Authors: Xiang Li; Tao Zhou; Hao Ma; Yoriko Heianza; Catherine M Champagne; Donald A Williamson; George A Bray; Frank M Sacks; Lu Qi Journal: Diabetes Obes Metab Date: 2020-08-20 Impact factor: 6.577
Authors: Qibin Qi; Tuomas O Kilpeläinen; Mary K Downer; Toshiko Tanaka; Caren E Smith; Ivonne Sluijs; Emily Sonestedt; Audrey Y Chu; Frida Renström; Xiaochen Lin; Lars H Ängquist; Jinyan Huang; Zhonghua Liu; Yanping Li; Muhammad Asif Ali; Min Xu; Tarunveer Singh Ahluwalia; Jolanda M A Boer; Peng Chen; Makoto Daimon; Johan Eriksson; Markus Perola; Yechiel Friedlander; Yu-Tang Gao; Denise H M Heppe; John W Holloway; Denise K Houston; Stavroula Kanoni; Yu-Mi Kim; Maarit A Laaksonen; Tiina Jääskeläinen; Nanette R Lee; Terho Lehtimäki; Rozenn N Lemaitre; Wei Lu; Robert N Luben; Ani Manichaikul; Satu Männistö; Pedro Marques-Vidal; Keri L Monda; Julius S Ngwa; Louis Perusse; Frank J A van Rooij; Yong-Bing Xiang; Wanqing Wen; Mary K Wojczynski; Jingwen Zhu; Ingrid B Borecki; Claude Bouchard; Qiuyin Cai; Cyrus Cooper; George V Dedoussis; Panos Deloukas; Luigi Ferrucci; Nita G Forouhi; Torben Hansen; Lene Christiansen; Albert Hofman; Ingegerd Johansson; Torben Jørgensen; Shigeru Karasawa; Kay-Tee Khaw; Mi-Kyung Kim; Kati Kristiansson; Huaixing Li; Xu Lin; Yongmei Liu; Kurt K Lohman; Jirong Long; Vera Mikkilä; Dariush Mozaffarian; Kari North; Oluf Pedersen; Olli Raitakari; Harri Rissanen; Jaakko Tuomilehto; Yvonne T van der Schouw; André G Uitterlinden; M Carola Zillikens; Oscar H Franco; E Shyong Tai; Xiao Ou Shu; David S Siscovick; Ulla Toft; W M Monique Verschuren; Peter Vollenweider; Nicholas J Wareham; Jacqueline C M Witteman; Wei Zheng; Paul M Ridker; Jae H Kang; Liming Liang; Majken K Jensen; Gary C Curhan; Louis R Pasquale; David J Hunter; Karen L Mohlke; Matti Uusitupa; L Adrienne Cupples; Tuomo Rankinen; Marju Orho-Melander; Tao Wang; Daniel I Chasman; Paul W Franks; Thorkild I A Sørensen; Frank B Hu; Ruth J F Loos; Jennifer A Nettleton; Lu Qi Journal: Hum Mol Genet Date: 2014-08-07 Impact factor: 6.150