| Literature DB >> 25104851 |
Qibin Qi1, Tuomas O Kilpeläinen2, Mary K Downer3, Toshiko Tanaka4, Caren E Smith5, Ivonne Sluijs6, Emily Sonestedt7, Audrey Y Chu8, Frida Renström7, Xiaochen Lin9, Lars H Ängquist10, Jinyan Huang11, Zhonghua Liu9, Yanping Li3, Muhammad Asif Ali3, Min Xu3, Tarunveer Singh Ahluwalia12, Jolanda M A Boer13, Peng Chen14, Makoto Daimon15, Johan Eriksson16, Markus Perola17, Yechiel Friedlander18, Yu-Tang Gao19, Denise H M Heppe20, John W Holloway21, Denise K Houston22, Stavroula Kanoni23, Yu-Mi Kim24, Maarit A Laaksonen25, Tiina Jääskeläinen26, Nanette R Lee27, Terho Lehtimäki28, Rozenn N Lemaitre29, Wei Lu30, Robert N Luben31, Ani Manichaikul32, Satu Männistö25, Pedro Marques-Vidal33, Keri L Monda34, Julius S Ngwa35, Louis Perusse36, Frank J A van Rooij37, Yong-Bing Xiang19, Wanqing Wen38, Mary K Wojczynski39, Jingwen Zhu40, Ingrid B Borecki39, Claude Bouchard41, Qiuyin Cai38, Cyrus Cooper42, George V Dedoussis43, Panos Deloukas44, Luigi Ferrucci4, Nita G Forouhi45, Torben Hansen46, Lene Christiansen47, Albert Hofman37, Ingegerd Johansson48, Torben Jørgensen49, Shigeru Karasawa50, Kay-Tee Khaw31, Mi-Kyung Kim51, Kati Kristiansson25, Huaixing Li40, Xu Lin40, Yongmei Liu52, Kurt K Lohman53, Jirong Long38, Vera Mikkilä54, Dariush Mozaffarian55, Kari North56, Oluf Pedersen46, Olli Raitakari57, Harri Rissanen25, Jaakko Tuomilehto58, Yvonne T van der Schouw6, André G Uitterlinden59, M Carola Zillikens60, Oscar H Franco37, E Shyong Tai61, Xiao Ou Shu38, David S Siscovick62, Ulla Toft49, W M Monique Verschuren13, Peter Vollenweider63, Nicholas J Wareham45, Jacqueline C M Witteman37, Wei Zheng38, Paul M Ridker64, Jae H Kang65, Liming Liang9, Majken K Jensen66, Gary C Curhan67, Louis R Pasquale68, David J Hunter69, Karen L Mohlke70, Matti Uusitupa71, L Adrienne Cupples72, Tuomo Rankinen41, Marju Orho-Melander7, Tao Wang73, Daniel I Chasman74, Paul W Franks75, Thorkild I A Sørensen76, Frank B Hu69, Ruth J F Loos77, Jennifer A Nettleton78, Lu Qi79.
Abstract
FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177,330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.Entities:
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Year: 2014 PMID： 25104851 PMCID： PMC4271061 DOI： 10.1093/hmg/ddu411
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150