Literature DB >> 27617137

Techniques and Approaches to Genetic Analyses in Nephrological Disorders.

Laurel K Willig1.   

Abstract

Inherited renal disease is a leading cause of morbidity and mortality in pediatric nephrology. High throughput advancements in genomics have led to greater understanding of the biologic underpinnings of these diseases. However, the underlying genetic changes explain only part of the molecular biology that contributes to disease manifestation and progression. Other omics technologies will provide a more complete picture of these cellular processes. This review discusses these omics technologies in the context of pediatric renal disease.

Entities:  

Keywords:  epigenomics; genomics; metabolomics; nephrology; next generation sequencing; proteomics; transcriptomics

Year:  2015        PMID： 27617137      PMCID： PMC4918702          DOI： 10.1055/s-0035-1557108

Source DB:  PubMed          Journal:  J Pediatr Genet        ISSN： 2146-460X


  119 in total

Review 1.  Next generation sequencing: chemistry, technology and applications.

Authors:  Pei Hui
Journal:  Top Curr Chem       Date:  2014

Review 2.  Next-generation sequencing platforms.

Authors:  Elaine R Mardis
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2013       Impact factor: 10.745

Review 3.  Epigenetics: a new way to look at kidney diseases.

Authors:  Pazit Beckerman; Yi-An Ko; Katalin Susztak
Journal:  Nephrol Dial Transplant       Date:  2014-03-27       Impact factor: 5.992

4.  Advances in Alport syndrome diagnosis using next-generation sequencing.

Authors:  Rosangela Artuso; Chiara Fallerini; Laura Dosa; Francesca Scionti; Maurizio Clementi; Guido Garosi; Laura Massella; Maria Carmela Epistolato; Roberta Mancini; Francesca Mari; Ilaria Longo; Francesca Ariani; Alessandra Renieri; Mirella Bruttini
Journal:  Eur J Hum Genet       Date:  2011-09-07       Impact factor: 4.246

5.  Identifying and mapping cell-type-specific chromatin programming of gene expression.

Authors:  Troels T Marstrand; John D Storey
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-27       Impact factor: 11.205

6.  Deleterious- and disease-allele prevalence in healthy individuals: insights from current predictions, mutation databases, and population-scale resequencing.

Authors:  Yali Xue; Yuan Chen; Qasim Ayub; Ni Huang; Edward V Ball; Matthew Mort; Andrew D Phillips; Katy Shaw; Peter D Stenson; David N Cooper; Chris Tyler-Smith
Journal:  Am J Hum Genet       Date:  2012-12-07       Impact factor: 11.025

Review 7.  RNA-Seq: a revolutionary tool for transcriptomics.

Authors:  Zhong Wang; Mark Gerstein; Michael Snyder
Journal:  Nat Rev Genet       Date:  2009-01       Impact factor: 53.242

8.  Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.

Authors:  Noboru Doi; Shuhei Zenno; Ryu Ueda; Hiroko Ohki-Hamazaki; Kumiko Ui-Tei; Kaoru Saigo
Journal:  Curr Biol       Date:  2003-01-08       Impact factor: 10.834

9.  Fetal urinary peptides to predict postnatal outcome of renal disease in fetuses with posterior urethral valves (PUV).

Authors:  Julie Klein; Chrystelle Lacroix; Cécile Caubet; Justyna Siwy; Petra Zürbig; Mohammed Dakna; Françoise Muller; Benjamin Breuil; Angelique Stalmach; William Mullen; Harald Mischak; Flavio Bandin; Bernard Monsarrat; Jean-Loup Bascands; Stéphane Decramer; Joost P Schanstra
Journal:  Sci Transl Med       Date:  2013-08-14       Impact factor: 17.956

10.  A comparison of methods for differential expression analysis of RNA-seq data.

Authors:  Charlotte Soneson; Mauro Delorenzi
Journal:  BMC Bioinformatics       Date:  2013-03-09       Impact factor: 3.169
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