C Schmiedt-Fehr1, C Basar-Eroglu. 1. Institute of Psychology and Cognition Research, University of Bremen, Grazer Str. 4, D-28359 Bremen, Germany. schmiedtfehr@uni-bremen.de
Abstract
OBJECTIVE: ERPs may be limited in validity when investigating inhibitory functions in later adulthood, as age-related increases in intraindividual variability and changes in EEG-oscillations are not considered. The present study compared averaged ERP peak and single trial time-frequency (TF) data analysis. METHODS: Go/NoGo ERP waves amplitude/latency measures were compared with a TF analysis estimating single trial event-related EEG spectral power enhancement and intertrial phase-locking (ITC) in delta and theta band. RESULTS: Age-related larger ITC was found for theta oscillations in the N2-P3 time range during NoGo, only. Discrepancies between N1/N2 ERP and TF results were obtained. Go/NoGo-P3 amplitude reductions in elderly were not related to an increased delta latency jitter. CONCLUSIONS: Discrepancies between ERPs and TF results challenge conclusions made about age-related changes in Go/NoGo-N2. Earlier reports of age-related changes in P3 are supported by the present results. The study implies age-related impairments in a general neuronal inhibition mechanism and a specific response inhibition mechanism. SIGNIFICANCE: The study indicates long-range communication impairments in the aged brain and the results are discussed considering hypotheses on increases in neural noise.
OBJECTIVE: ERPs may be limited in validity when investigating inhibitory functions in later adulthood, as age-related increases in intraindividual variability and changes in EEG-oscillations are not considered. The present study compared averaged ERP peak and single trial time-frequency (TF) data analysis. METHODS: Go/NoGo ERP waves amplitude/latency measures were compared with a TF analysis estimating single trial event-related EEG spectral power enhancement and intertrial phase-locking (ITC) in delta and theta band. RESULTS: Age-related larger ITC was found for theta oscillations in the N2-P3 time range during NoGo, only. Discrepancies between N1/N2 ERP and TF results were obtained. Go/NoGo-P3 amplitude reductions in elderly were not related to an increased delta latency jitter. CONCLUSIONS: Discrepancies between ERPs and TF results challenge conclusions made about age-related changes in Go/NoGo-N2. Earlier reports of age-related changes in P3 are supported by the present results. The study implies age-related impairments in a general neuronal inhibition mechanism and a specific response inhibition mechanism. SIGNIFICANCE: The study indicates long-range communication impairments in the aged brain and the results are discussed considering hypotheses on increases in neural noise.
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