Literature DB >> 21114249

Statistical treatment of photon/electron counting: extending the linear dynamic range from the dark count rate to saturation.

David J Kissick1, Ryan D Muir, Garth J Simpson.   

Abstract

An experimentally simple photon counting method is demonstrated providing 7 orders of magnitude in linear dynamic range (LDR) for a single photomultiplier tube (PMT) detector. In conventional photon/electron counting methods, the linear range is dictated by the agreement between the binomially distributed measurement of counted events and the underlying Poisson distribution of photons/electrons. By explicitly considering the log-normal probability distribution in voltage transients as a function of the number of photons present and the Poisson distribution of photons, observed counts for a given threshold can be related to the mean number of photons well beyond the conventional limit. Analytical expressions are derived relating counts and photons that extend the linear range to an average of ∼11 photons arriving simultaneously with a single threshold. These expressions can be evaluated numerically for multiple thresholds extending the linear range to the saturation point of the PMT. The peak voltage distributions are experimentally shown to follow a Poisson weighted sum of log-normal distributions that can all be derived from the single photoelectron voltage peak-height distribution. The LDR that results from this method is compared to conventional single photon counting (SPC) and to signal averaging by analog to digital conversion (ADC).

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Year:  2010        PMID: 21114249      PMCID: PMC3025609          DOI: 10.1021/ac102219c

Source DB:  PubMed          Journal:  Anal Chem        ISSN: 0003-2700            Impact factor:   6.986


  3 in total

1.  Critical comparison of photon counting and direct current measurement techniques for quantitative spectrometric methods.

Authors:  J D Ingle; S R Crouch
Journal:  Anal Chem       Date:  1972-04-01       Impact factor: 6.986

2.  Optimization of multi-photon event discrimination levels using Poisson statistics.

Authors:  Juri Soukka; Arho Virkki; Pekka Hänninen; Juhani Soini
Journal:  Opt Express       Date:  2004-01-12       Impact factor: 3.894

3.  Six orders of magnitude dynamic range in capillary electrophoresis with ultrasensitive laser-induced fluorescence detection.

Authors:  Colin D Whitmore; David Essaka; Norman J Dovichi
Journal:  Talanta       Date:  2009-08-05       Impact factor: 6.057

  3 in total
  10 in total

1.  Synchronous digitization for high dynamic range lock-in amplification in beam-scanning microscopy.

Authors:  Ryan D Muir; Shane Z Sullivan; Robert A Oglesbee; Garth J Simpson
Journal:  Rev Sci Instrum       Date:  2014-03       Impact factor: 1.523

2.  High frame-rate multichannel beam-scanning microscopy based on Lissajous trajectories.

Authors:  Shane Z Sullivan; Ryan D Muir; Justin A Newman; Mark S Carlsen; Suhas Sreehari; Chris Doerge; Nathan J Begue; R Michael Everly; Charles A Bouman; Garth J Simpson
Journal:  Opt Express       Date:  2014-10-06       Impact factor: 3.894

3.  Enhancing the Linear Dynamic Range in Multi-Channel Single Photon Detector beyond 7OD.

Authors:  Dmytro Gudkov; George Gudkov; Boris Gorbovitski; Vera Gorfinkel
Journal:  IEEE Sens J       Date:  2015-08-21       Impact factor: 3.301

4.  Guiding synchrotron X-ray diffraction by multimodal video-rate protein crystal imaging.

Authors:  Justin A Newman; Shijie Zhang; Shane Z Sullivan; Ximeng Y Dow; Michael Becker; Michael J Sheedlo; Sergey Stepanov; Mark S Carlsen; R Michael Everly; Chittaranjan Das; Robert F Fischetti; Garth J Simpson
Journal:  J Synchrotron Radiat       Date:  2016-05-16       Impact factor: 2.616

5.  Nine orders of magnitude dynamic range: picomolar to millimolar concentration measurement in capillary electrophoresis with laser induced fluorescence detection employing cascaded avalanche photodiode photon counters.

Authors:  Oluwatosin O Dada; David C Essaka; Ole Hindsgaul; Monica M Palcic; Jillian Prendergast; Ronald L Schnaar; Norman J Dovichi
Journal:  Anal Chem       Date:  2011-03-16       Impact factor: 6.986

6.  Real-time dynamic range and signal to noise enhancement in beam-scanning microscopy by integration of sensor characteristics, data acquisition hardware, and statistical methods.

Authors:  David J Kissick; Ryan D Muir; Shane Z Sullivan; Robert A Oglesbee; Garth J Simpson
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2013-02-14

7.  Statistical connection of binomial photon counting and photon averaging in high dynamic range beam-scanning microscopy.

Authors:  Ryan D Muir; David J Kissick; Garth J Simpson
Journal:  Opt Express       Date:  2012-04-23       Impact factor: 3.894

8.  Modeling truncated pixel values of faint reflections in MicroED images.

Authors:  Johan Hattne; Dan Shi; M Jason de la Cruz; Francis E Reyes; Tamir Gonen
Journal:  J Appl Crystallogr       Date:  2016-05-11       Impact factor: 3.304

9.  Digital deconvolution filter derived from linear discriminant analysis and application for multiphoton fluorescence microscopy.

Authors:  Shane Z Sullivan; Paul D Schmitt; Ryan D Muir; Emma L DeWalt; Garth J Simpson
Journal:  Anal Chem       Date:  2014-03-11       Impact factor: 6.986

10.  Real-time high dynamic range laser scanning microscopy.

Authors:  C Vinegoni; C Leon Swisher; P Fumene Feruglio; R J Giedt; D L Rousso; S Stapleton; R Weissleder
Journal:  Nat Commun       Date:  2016-04-01       Impact factor: 14.919

  10 in total

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