Literature DB >> 21081125

Chromatin structure as a mediator of aging.

Jason Feser1, Jessica Tyler.   

Abstract

The aging process is characterized by gradual changes to an organism's macromolecules, which negatively impacts biological processes. The complex macromolecular structure of chromatin regulates all nuclear processes requiring access to the DNA sequence. As such, maintenance of chromatin structure is an integral component to deter premature aging. In this review, we describe current research that links aging to chromatin structure. Histone modifications influence chromatin compaction and gene expression and undergo many changes during aging. Histone protein levels also decline during aging, dramatically affecting chromatin structure. Excitingly, lifespan can be extended by manipulations that reverse the age-dependent changes to chromatin structure, indicating the pivotal role chromatin structure plays during aging.
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 21081125      PMCID： PMC3988783          DOI： 10.1016/j.febslet.2010.11.016

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  70 in total

1.  Accumulation of senescent cells in mitotic tissue of aging primates.

Authors:  Jessie C Jeyapalan; Mark Ferreira; John M Sedivy; Utz Herbig
Journal:  Mech Ageing Dev       Date:  2006-11-20       Impact factor: 5.432

2.  Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila.

Authors:  Gábor Juhász; Balázs Erdi; Miklós Sass; Thomas P Neufeld
Journal:  Genes Dev       Date:  2007-12-01       Impact factor: 11.361

3.  Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging.

Authors:  Dale K Shumaker; Thomas Dechat; Alexander Kohlmaier; Stephen A Adam; Matthew R Bozovsky; Michael R Erdos; Maria Eriksson; Anne E Goldman; Satya Khuon; Francis S Collins; Thomas Jenuwein; Robert D Goldman
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-31       Impact factor: 11.205

Review 4.  Hutchinson-Gilford progeria syndrome: review of the phenotype.

Authors:  Raoul C M Hennekam
Journal:  Am J Med Genet A       Date:  2006-12-01       Impact factor: 2.802

Review 5.  Genome dynamics and transcriptional deregulation in aging.

Authors:  R Busuttil; R Bahar; J Vijg
Journal:  Neuroscience       Date:  2006-11-28       Impact factor: 3.590

Review 6.  Cross-talk between aging and cancer: the epigenetic language.

Authors:  Mario F Fraga; Ruben Agrelo; Manel Esteller
Journal:  Ann N Y Acad Sci       Date:  2007-04       Impact factor: 5.691

Review 7.  The role of nuclear architecture in genomic instability and ageing.

Authors:  Philipp Oberdoerffer; David A Sinclair
Journal:  Nat Rev Mol Cell Biol       Date:  2007-09       Impact factor: 94.444

Review 8.  Epigenetics and aging: the targets and the marks.

Authors:  Mario F Fraga; Manel Esteller
Journal:  Trends Genet       Date:  2007-06-07       Impact factor: 11.639

9.  Changes in histone acetylation during postovulatory aging of mouse oocyte.

Authors:  Jun-Cheng Huang; Li-Ying Yan; Zi-Li Lei; Yi-Liang Miao; Li-Hong Shi; Ji-Wen Yang; Qiang Wang; Ying-Chun Ouyang; Qing-Yuan Sun; Da-Yuan Chen
Journal:  Biol Reprod       Date:  2007-06-20       Impact factor: 4.285

10.  The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.

Authors:  Adrian P Bracken; Daniela Kleine-Kohlbrecher; Nikolaj Dietrich; Diego Pasini; Gaetano Gargiulo; Chantal Beekman; Kim Theilgaard-Mönch; Saverio Minucci; Bo T Porse; Jean-Christophe Marine; Klaus H Hansen; Kristian Helin
Journal:  Genes Dev       Date:  2007-03-01       Impact factor: 11.361
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  79 in total

Review 1.  Epigenetic regulation of ageing: linking environmental inputs to genomic stability.

Authors:  Bérénice A Benayoun; Elizabeth A Pollina; Anne Brunet
Journal:  Nat Rev Mol Cell Biol       Date:  2015-09-16       Impact factor: 94.444

Review 2.  Aging and epigenetic drift: a vicious cycle.

Authors:  Jean-Pierre Issa
Journal:  J Clin Invest       Date:  2014-01-02       Impact factor: 14.808

Review 3.  Histone methylation and aging: lessons learned from model systems.

Authors:  Brenna S McCauley; Weiwei Dang
Journal:  Biochim Biophys Acta       Date:  2014-05-21

Review 4.  The Retrotransposon storm and the dangers of a Collyer's genome.

Authors:  Josh Dubnau
Journal:  Curr Opin Genet Dev       Date:  2018-05-08       Impact factor: 5.578

Review 5.  Epigenetics and chromatin dynamics: a review and a paradigm for functional disorders.

Authors:  T Ordog; S A Syed; Y Hayashi; D T Asuzu
Journal:  Neurogastroenterol Motil       Date:  2012-10-24       Impact factor: 3.598

6.  Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response.

Authors:  Weiwei Dang; George L Sutphin; Jean A Dorsey; Gabriel L Otte; Kajia Cao; Rocco M Perry; Jennifer J Wanat; Dimitra Saviolaki; Christopher J Murakami; Scott Tsuchiyama; Brett Robison; Brian D Gregory; Michiel Vermeulen; Ramin Shiekhattar; F Brad Johnson; Brian K Kennedy; Matt Kaeberlein; Shelley L Berger
Journal:  Cell Metab       Date:  2014-05-08       Impact factor: 27.287

Review 7.  Protein homeostasis: live long, won't prosper.

Authors:  Brandon H Toyama; Martin W Hetzer
Journal:  Nat Rev Mol Cell Biol       Date:  2013-01       Impact factor: 94.444

8.  Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila.

Authors:  Jason G Wood; Brian C Jones; Nan Jiang; Chengyi Chang; Suzanne Hosier; Priyan Wickremesinghe; Meyrolin Garcia; Davis A Hartnett; Lucas Burhenn; Nicola Neretti; Stephen L Helfand
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-12       Impact factor: 11.205

Review 9.  Histone variants: the tricksters of the chromatin world.

Authors:  Catherine Volle; Yamini Dalal
Journal:  Curr Opin Genet Dev       Date:  2014-01-24       Impact factor: 5.578

10.  Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence.

Authors:  Akira Tsujii; Yoichi Miyamoto; Tetsuji Moriyama; Yuko Tsuchiya; Chikashi Obuse; Kenji Mizuguchi; Masahiro Oka; Yoshihiro Yoneda
Journal:  J Biol Chem       Date:  2015-10-21       Impact factor: 5.157
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