Literature DB >> 24382386

Aging and epigenetic drift: a vicious cycle.

Jean-Pierre Issa.   

Abstract

The term epigenetics refers to stable patterns of gene expression that are seen during differentiation or X chromosome inactivation and are not dependent on dynamic changes in coding DNA. These gene expression states are encoded in the epigenome - a collection of marks on DNA or on histone tails that are established during embryogenesis. Genome-wide studies in aging cells and tissues have uncovered stochastic DNA methylation drift (gradual increases or decreases at specific loci) that reflects imperfect maintenance of epigenetic marks. Drift creates epigenetic mosaicism in aging stem cells that could potentially restrict their plasticity and worsen phenotypes such as stem cell exhaustion and focal proliferative defects that can lead to cancer.

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Year:  2014        PMID： 24382386      PMCID： PMC3871228          DOI： 10.1172/JCI69735

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  83 in total

1.  Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.

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Journal:  Mol Cell       Date:  2003-12       Impact factor: 17.970

2.  Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer.

Authors:  Marcos R H Estécio; Juan Gallegos; Céline Vallot; Ryan J Castoro; Woonbok Chung; Shinji Maegawa; Yasuhiro Oki; Yutaka Kondo; Jaroslav Jelinek; Lanlan Shen; Helge Hartung; Peter D Aplan; Bogdan A Czerniak; Shoudan Liang; Jean-Pierre J Issa
Journal:  Genome Res       Date:  2010-08-17       Impact factor: 9.043

Review 3.  Polycomb silencers control cell fate, development and cancer.

Authors:  Anke Sparmann; Maarten van Lohuizen
Journal:  Nat Rev Cancer       Date:  2006-11       Impact factor: 60.716

Review 4.  The role of mutations in epigenetic regulators in myeloid malignancies.

Authors:  Alan H Shih; Omar Abdel-Wahab; Jay P Patel; Ross L Levine
Journal:  Nat Rev Cancer       Date:  2012-08-17       Impact factor: 60.716

Review 5.  Stem cells and their implications for colorectal cancer.

Authors:  Sebastian S Zeki; Trevor A Graham; Nicholas A Wright
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2011-02       Impact factor: 46.802

6.  Chromatin remodeling in the aging genome of Drosophila.

Authors:  Jason G Wood; Sara Hillenmeyer; Charles Lawrence; Chengyi Chang; Suzanne Hosier; Will Lightfoot; Eric Mukherjee; Nan Jiang; Christoph Schorl; Alexander S Brodsky; Nicola Neretti; Stephen L Helfand
Journal:  Aging Cell       Date:  2010-10-21       Impact factor: 9.304

7.  Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells.

Authors:  Tohru Niwa; Tetsuya Tsukamoto; Takeshi Toyoda; Akiko Mori; Harunari Tanaka; Takao Maekita; Masao Ichinose; Masae Tatematsu; Toshikazu Ushijima
Journal:  Cancer Res       Date:  2010-02-02       Impact factor: 12.701

8.  Cellular differentiation, cytidine analogs and DNA methylation.

Authors:  P A Jones; S M Taylor
Journal:  Cell       Date:  1980-05       Impact factor: 41.582

Review 9.  Inferring human stem cell behaviour from epigenetic drift.

Authors:  D Shibata
Journal:  J Pathol       Date:  2009-01       Impact factor: 7.996

10.  Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs.

Authors:  Rudolf P Talens; Kaare Christensen; Hein Putter; Gonneke Willemsen; Lene Christiansen; Dennis Kremer; H Eka D Suchiman; P Eline Slagboom; Dorret I Boomsma; Bastiaan T Heijmans
Journal:  Aging Cell       Date:  2012-06-04       Impact factor: 9.304
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  135 in total

1.  DNA Methyltransferase 1 Is Dysregulated in Parkinson's Disease via Mediation of miR-17.

Authors:  Hong-Qiu Zhang; Jian-Yong Wang; Zhao-Feng Li; Lei Cui; Shi-Shi Huang; Lan-Bing Zhu; Yue Sun; Rui Yang; Hui-Hui Fan; Xiong Zhang; Jian-Hong Zhu
Journal:  Mol Neurobiol       Date:  2021-01-22       Impact factor: 5.590

Review 2.  Epigenetics in lung fibrosis: from pathobiology to treatment perspective.

Authors:  Britney A Helling; Ivana V Yang
Journal:  Curr Opin Pulm Med       Date:  2015-09       Impact factor: 3.155

Review 3.  Epigenetic mechanisms of neuroplasticity and the implications for stroke recovery.

Authors:  Ryan J Felling; Hongjun Song
Journal:  Exp Neurol       Date:  2014-09-26       Impact factor: 5.330

Review 4.  Targeting Age-Related Pathways in Heart Failure.

Authors:  Haobo Li; Margaret H Hastings; James Rhee; Lena E Trager; Jason D Roh; Anthony Rosenzweig
Journal:  Circ Res       Date:  2020-02-13       Impact factor: 17.367

Review 5.  The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening.

Authors:  William M Grady; Sanford D Markowitz
Journal:  Dig Dis Sci       Date:  2014-12-10       Impact factor: 3.199

Review 6.  The biology of aging and lymphoma: a complex interplay.

Authors:  Clémentine Sarkozy; Gilles Salles; Claire Falandry
Journal:  Curr Oncol Rep       Date:  2015-07       Impact factor: 5.075

7.  Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer's Disease Subjects.

Authors:  Elizabeth M Ellison; Melissa A Bradley-Whitman; Mark A Lovell
Journal:  J Mol Neurosci       Date:  2017-09-02       Impact factor: 3.444

8.  No effect of weight loss on LINE-1 methylation levels in peripheral blood leukocytes from postmenopausal overweight women.

Authors:  Catherine Duggan; Liren Xiao; Mary Beth Terry; Anne McTiernan
Journal:  Obesity (Silver Spring)       Date:  2014-06-13       Impact factor: 5.002

9.  Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer.

Authors:  Hanghang Zhang; Somnath Pandey; Meghan Travers; Hongxing Sun; George Morton; Jozef Madzo; Woonbok Chung; Jittasak Khowsathit; Oscar Perez-Leal; Carlos A Barrero; Carmen Merali; Yasuyuki Okamoto; Takahiro Sato; Joshua Pan; Judit Garriga; Natarajan V Bhanu; Johayra Simithy; Bela Patel; Jian Huang; Noël J-M Raynal; Benjamin A Garcia; Marlene A Jacobson; Cigall Kadoch; Salim Merali; Yi Zhang; Wayne Childers; Magid Abou-Gharbia; John Karanicolas; Stephen B Baylin; Cynthia A Zahnow; Jaroslav Jelinek; Xavier Graña; Jean-Pierre J Issa
Journal:  Cell       Date:  2018-10-25       Impact factor: 41.582

Review 10.  Epigenetic Determinants of Cancer.

Authors:  Stephen B Baylin; Peter A Jones
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-09-01       Impact factor: 10.005
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