Literature DB >> 21073153

Cooperative melting in caged dimers with only two DNA duplexes.

Ibrahim Eryazici1, Tatiana R Prytkova, George C Schatz, SonBinh T Nguyen.   

Abstract

Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

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Year:  2010        PMID： 21073153      PMCID： PMC3657612          DOI： 10.1021/ja107232x

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  12 in total

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