PURPOSE: To evaluate radiation dermatitis objectively in patients with breast cancer who had undergone post-operative radiotherapy after breast-conserving surgery. PATIENTS AND METHODS: Skin color (L*, a*, and b* values) and moisture analyses were performed for both breasts (before, after, 1 month, 6 months, and 1 year after radiotherapy) to examine irradiated and non-irradiated skin divided into four quadrants in 118 patients. These patients underwent breast conservative surgery followed by 50 Gy/25 fractions (median) of radiotherapy with or without boost irradiation (10 Gy/5 fractions). RESULTS: L*, a*, and moisture values were changed by irradiation and maximized at completion or 1 month after radiotherapy. One year after radiotherapy, the skin color had returned to the range observed prior to radiotherapy. However, moisture did not return to previous values even 1 year after treatment. The lateral upper side (quadrant C) showed greater changes than other quadrants in the L* value (darker) at the end of radiotherapy. The Common Toxicity Criteria version 3 scores were found to correlate well with a* and L* values at the completion and 1 month after radiotherapy. Boost radiotherapy intensified reddish and darker color changes at the completion of radiotherapy, while chemotherapy did not intensify the skin reaction caused by radiotherapy. CONCLUSION: Moisture impairment as a result of irradiation lasts longer than color alterations. Objective assessments are useful for analyzing radiation dermatitis.
PURPOSE: To evaluate radiation dermatitis objectively in patients with breast cancer who had undergone post-operative radiotherapy after breast-conserving surgery. PATIENTS AND METHODS: Skin color (L*, a*, and b* values) and moisture analyses were performed for both breasts (before, after, 1 month, 6 months, and 1 year after radiotherapy) to examine irradiated and non-irradiated skin divided into four quadrants in 118 patients. These patients underwent breast conservative surgery followed by 50 Gy/25 fractions (median) of radiotherapy with or without boost irradiation (10 Gy/5 fractions). RESULTS: L*, a*, and moisture values were changed by irradiation and maximized at completion or 1 month after radiotherapy. One year after radiotherapy, the skin color had returned to the range observed prior to radiotherapy. However, moisture did not return to previous values even 1 year after treatment. The lateral upper side (quadrant C) showed greater changes than other quadrants in the L* value (darker) at the end of radiotherapy. The Common Toxicity Criteria version 3 scores were found to correlate well with a* and L* values at the completion and 1 month after radiotherapy. Boost radiotherapy intensified reddish and darker color changes at the completion of radiotherapy, while chemotherapy did not intensify the skin reaction caused by radiotherapy. CONCLUSION:Moisture impairment as a result of irradiation lasts longer than color alterations. Objective assessments are useful for analyzing radiation dermatitis.
Authors: U Heinrich; U Koop; M-C Leneveu-Duchemin; K Osterrieder; S Bielfeldt; C Chkarnat; J Degwert; D Häntschel; S Jaspers; H-P Nissen; M Rohr; G Schneider; H Tronnier Journal: Int J Cosmet Sci Date: 2003-04 Impact factor: 2.970
Authors: Liu Wei; Wang Xuemin; Lai Wei; Li Li; Zhang Ping; Wu Yanyu; Lu Ying; Li Yan; Tian Yan; Wu Yan; Chen Li Journal: Int J Dermatol Date: 2007-08 Impact factor: 2.736
Authors: Yasser Abo-Madyan; Martin Polednik; Angelika Rahn; Frank Schneider; Barbara Dobler; Frederik Wenz; Frank Lohr Journal: Strahlenther Onkol Date: 2008-02 Impact factor: 3.621
Authors: Y Huang; J Sanz; N Rodríguez; X Duran; A Martínez; X Li; P Foro; M Conde; M Zhao; F Liu; A Reig; J Dengra; I Membrive; P Pérez; M Algara Journal: Clin Transl Oncol Date: 2021-11-18 Impact factor: 3.340
Authors: Dae Sik Yang; Jung Ae Lee; Won Sup Yoon; Nam Kwon Lee; Young Je Park; Suk Lee; Chul Yong Kim; Gil Soo Son Journal: Biomed Res Int Date: 2016-08-07 Impact factor: 3.411