PURPOSE: To assess the effect of cataract on the evaluation of macular pigment optical density (MPOD) in aged patients. METHODS: MPOD was prospectively measured using autofluorescence spectrometry before and after cataract surgery. The Lens Opacities Classification System III was used to grade the cataracts at baseline. RESULTS: Forty-five eyes of 41 subjects, who had no ocular disorders or fundus autofluorescence abnormalities except for age-related nuclear cataract, were included. Preoperative MPOD was 0.350 ± 0.117 density unit (DU). Regression analysis showed that a higher nuclear color score correlated with lower MPOD (t = -2.90, P = 0.0063). The preoperative MPOD prediction formula was MPOD = 0.545 - 0.069 × nuclear color score. A higher nuclear color score correlated significantly with failure to measure the MPOD (χ(2) = 5.08, P = 0.0242). The mean postoperative MPOD was 0.600 DU (95% confidence interval [CI], 0.562-0.637), which was significantly (P < 0.0001) higher than the preoperative level of 0.350 DU (95% CI, 0.313-0.388). Regression analysis showed that higher preoperative MPOD correlated with higher postoperative MPOD (t = 2.91, P = 0.0061). CONCLUSIONS: Cataract, especially its nuclear component, affects MPOD measured by autofluorescence spectrometry. Care should be taken when using this method in eyes with age-related macular maculopathy and age-related macular degeneration and in older patients who may develop these diseases.
PURPOSE: To assess the effect of cataract on the evaluation of macular pigment optical density (MPOD) in aged patients. METHODS: MPOD was prospectively measured using autofluorescence spectrometry before and after cataract surgery. The Lens Opacities Classification System III was used to grade the cataracts at baseline. RESULTS: Forty-five eyes of 41 subjects, who had no ocular disorders or fundus autofluorescence abnormalities except for age-related nuclear cataract, were included. Preoperative MPOD was 0.350 ± 0.117 density unit (DU). Regression analysis showed that a higher nuclear color score correlated with lower MPOD (t = -2.90, P = 0.0063). The preoperative MPOD prediction formula was MPOD = 0.545 - 0.069 × nuclear color score. A higher nuclear color score correlated significantly with failure to measure the MPOD (χ(2) = 5.08, P = 0.0242). The mean postoperative MPOD was 0.600 DU (95% confidence interval [CI], 0.562-0.637), which was significantly (P < 0.0001) higher than the preoperative level of 0.350 DU (95% CI, 0.313-0.388). Regression analysis showed that higher preoperative MPOD correlated with higher postoperative MPOD (t = 2.91, P = 0.0061). CONCLUSIONS:Cataract, especially its nuclear component, affects MPOD measured by autofluorescence spectrometry. Care should be taken when using this method in eyes with age-related macular maculopathy and age-related macular degeneration and in older patients who may develop these diseases.
Authors: Paul S Bernstein; Faisal Ahmed; Aihua Liu; Susan Allman; Xiaoming Sheng; Mohsen Sharifzadeh; Igor Ermakov; Werner Gellermann Journal: Invest Ophthalmol Vis Sci Date: 2012-09-14 Impact factor: 4.799
Authors: Ambreen Tariq; Omar A Mahroo; Katie M Williams; S H Melissa Liew; Stephen Beatty; Clare E Gilbert; Frederik J Van Kuijk; Christopher J Hammond Journal: Invest Ophthalmol Vis Sci Date: 2014-04-07 Impact factor: 4.799