PURPOSE: Relationships between follicular fluid levels of IL-6 with ovarian response and clinical pregnancy were evaluated in IVF-ET cycles. METHODS: Follicular fluid was collected from ovarian follicles ≥ 14 mm, pooled for each patient, and IL-6 levels were assessed using ELISA (n = 68). Relationships between IL-6 levels and IVF cycle parameters were assessed using nonparametric tests, and between IL-6 levels and clinical pregnancy using multivariable logistic regression analyses. RESULTS: Significant positive correlations were observed between IL-6 with age (p = 0.035), and IL-6 with estradiol on the day of hCG (p = 0.011). On adjusted analyses, IVF cycles in patients with IL-6 levels <4.0 pg/ml (median value for the group) demonstrated an almost 4-fold increase in likelihood for clinical pregnancy (p = 0.045). CONCLUSIONS: Lower follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. We hypothesize that endometrial receptivity is a likely target for any deleterious influences of elevated IL-6 levels.
PURPOSE: Relationships between follicular fluid levels of IL-6 with ovarian response and clinical pregnancy were evaluated in IVF-ET cycles. METHODS: Follicular fluid was collected from ovarian follicles ≥ 14 mm, pooled for each patient, and IL-6 levels were assessed using ELISA (n = 68). Relationships between IL-6 levels and IVF cycle parameters were assessed using nonparametric tests, and between IL-6 levels and clinical pregnancy using multivariable logistic regression analyses. RESULTS: Significant positive correlations were observed between IL-6 with age (p = 0.035), and IL-6 with estradiol on the day of hCG (p = 0.011). On adjusted analyses, IVF cycles in patients with IL-6 levels <4.0 pg/ml (median value for the group) demonstrated an almost 4-fold increase in likelihood for clinical pregnancy (p = 0.045). CONCLUSIONS: Lower follicular fluid IL-6 levels in IVFpatients are associated with increased likelihood of clinical pregnancy. We hypothesize that endometrial receptivity is a likely target for any deleterious influences of elevated IL-6 levels.
Authors: Mohamad Eid Hammadeh; A Kubily Ertan; Michael Zeppezauer; Sabine Baltes; Thomas Georg; Peter Rosenbaum; Werner Schmidt Journal: Am J Reprod Immunol Date: 2002-02 Impact factor: 3.886
Authors: P G Artini; M Monti; A Fasciani; C Battaglia; G D'Ambrogio; A R Genazzani Journal: Eur J Obstet Gynecol Reprod Biol Date: 2002-03-10 Impact factor: 2.435
Authors: Louisa A Rispoli; J Lannett Edwards; Ky G Pohler; Stephen Russell; Richard I Somiari; Rebecca R Payton; F Neal Schrick Journal: PLoS One Date: 2019-12-30 Impact factor: 3.240