Jie Yang1, Xiaoling Yang1, Hong Yang1, Yang Bai1, Hao Zha1, Fangjie Jiang1, Yushi Meng2. 1. Reproduction Center, The Second Affiliated Hospital of Kunming Medical University, Dianmian Road 374, Kunming, 650101, Yunnan Province, China. 2. Reproduction Center, The Second Affiliated Hospital of Kunming Medical University, Dianmian Road 374, Kunming, 650101, Yunnan Province, China. mengyushikm@126.com.
Abstract
PURPOSE: The aim of this study was to evaluate the role of interleukin 6 in embryo development in the in vitro fertilization cycles. METHODS: This was a retrospective cohort study. One hundred and three women undergoing in vitro fertilization and embryo transfer due to a tubal factor were included in the study. The follicular fluid IL-6 levels on oocyte retrieval day from each patient were determined by ELISA. The relationships between follicular fluid IL-6 levels and IVF cycle parameters were investigated. RESULTS: The levels of follicular fluid IL-6 were not affected by the use of drugs for superovulation or by estrogen. In addition, follicular fluid IL-6 levels did not affect the number of oocytes retrieved or the MII oocyte rate. High levels of follicular fluid IL-6 correlated with a significant increase in the rates of clinical pregnancy. Follicular fluid IL-6 levels did not affect the cell number or the blastomere symmetry of day 3 embryos, but it did significantly reduce the embryo fragmentation rate. CONCLUSIONS: High levels of follicular fluid IL-6 improved the rates of clinical pregnancy and reduce embryo fragmentation.
PURPOSE: The aim of this study was to evaluate the role of interleukin 6 in embryo development in the in vitro fertilization cycles. METHODS: This was a retrospective cohort study. One hundred and three women undergoing in vitro fertilization and embryo transfer due to a tubal factor were included in the study. The follicular fluid IL-6 levels on oocyte retrieval day from each patient were determined by ELISA. The relationships between follicular fluid IL-6 levels and IVF cycle parameters were investigated. RESULTS: The levels of follicular fluid IL-6 were not affected by the use of drugs for superovulation or by estrogen. In addition, follicular fluid IL-6 levels did not affect the number of oocytes retrieved or the MII oocyte rate. High levels of follicular fluid IL-6 correlated with a significant increase in the rates of clinical pregnancy. Follicular fluid IL-6 levels did not affect the cell number or the blastomere symmetry of day 3 embryos, but it did significantly reduce the embryo fragmentation rate. CONCLUSIONS: High levels of follicular fluid IL-6 improved the rates of clinical pregnancy and reduce embryo fragmentation.
Entities:
Keywords:
Embryo development potential; Embryo fragmentation; Embryo implantation; IL-6
Authors: Zhilin Liu; Daniel G de Matos; Heng-Yu Fan; Masayuki Shimada; Stephen Palmer; JoAnne S Richards Journal: Endocrinology Date: 2009-03-19 Impact factor: 4.736
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