| Literature DB >> 21045869 |
Gustavo de los Campos1, Daniel Gianola, David B Allison.
Abstract
Although genome-wide association studies have identified markers that are associated with various human traits and diseases, our ability to predict such phenotypes remains limited. A perhaps overlooked explanation lies in the limitations of the genetic models and statistical techniques commonly used in association studies. We propose that alternative approaches, which are largely borrowed from animal breeding, provide potential for advances. We review selected methods and discuss the challenges and opportunities ahead.Entities:
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Year: 2010 PMID： 21045869 DOI： 10.1038/nrg2898
Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242