| Literature DB >> 21028867 |
Yuta Sannohe1, Masayuki Endo, Yousuke Katsuda, Kumi Hidaka, Hiroshi Sugiyama.
Abstract
We herein report the real-time observation of G-quadruplex formation by monitoring the G-quadruplex-induced global change of two duplexes incorporated in a DNA nanoscaffold. The introduced G-rich strands formed an interstrand (3 + 1) G-quadruplex structure in the presence of K(+), and the formed four-stranded structure was disrupted by removal of K(+). These conformational changes were visualized in a nanoscaffold in real-time with fast-scanning atomic force microscopy.Mesh：
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Year: 2010 PMID： 21028867 DOI： 10.1021/ja1058907
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419