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Literature DB >> 2098694

Prebiotic synthesis of orotic acid parallel to the biosynthetic pathway.

Y Yamagata¹, K Sasaki, O Takaoka, S Sano, K Inomata, K Kanemitsu, Y Inoue, I Matsumoto.

Abstract

By heating an aqueous solution of aspartic acid and urea, carbamylaspartic acid is first formed and then the molecule is cyclized to dihydroorotic acid (DHO) with loss of water. Irradiation of an aqueous solution of DHO with a tungsten lamp yields orotic acid by photo-dehydrogenation of the molecule. This pathway of orotic acid formation is quite similar to that of biosynthesis of the molecule.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1990 PMID： 2098694 DOI： 10.1007/bf01808133

Source DB: PubMed Journal: Orig Life Evol Biosph ISSN： 0169-6149 Impact factor: 1.950

20 in total

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Journal: Tetrahedron Date: 1984 Impact factor: 2.457

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Journal: Proc Natl Acad Sci U S A Date: 1972-03 Impact factor: 11.205

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Authors: A W Schwartz; A B Voet; M Van der Veen
Journal: Orig Life Date: 1984

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Authors: M Sakurai; H Yanagawa
Journal: Orig Life Date: 1984

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Authors: S W FOX; K HARADA
Journal: Science Date: 1961-06-16 Impact factor: 47.728

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Authors: A B Voet; A W Schwartz
Journal: Orig Life Date: 1982-03

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Authors: I LIEBERMAN; A KORNBERG
Journal: J Biol Chem Date: 1954-04 Impact factor: 5.157

7 in total

1. Which way to life?

Authors: Antonio Lazcano
Journal: Orig Life Evol Biosph Date: 2010-03-03 Impact factor: 1.950

2. Orotidine-Containing RNA: Implications for the Hierarchical Selection (Systems Chemistry Emergence) of RNA.

Authors: Eun-Kyong Kim; Vincent Martin; Ramanarayanan Krishnamurthy
Journal: Chemistry Date: 2017-08-11 Impact factor: 5.236

3. Does formate reduce alpha-ketoglutarate and ammonia to glutamate?

Authors: Q Maughan; S L Miller
Journal: Orig Life Evol Biosph Date: 1999-08 Impact factor: 1.950

4. Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways.

Authors: Sunil Pulletikurti; Mahipal Yadav; Greg Springsteen; Ramanarayanan Krishnamurthy
Journal: Nat Chem Date: 2022-07-28 Impact factor: 24.274