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Literature DB >> 4501592

Prebiotic synthesis of hydrophobic and protein amino acids.

D Ring, Y Wolman, N Friedmann, S L Miller.

Abstract

The formation of amino acids by the action of electric discharges on a mixture of methane, nitrogen, and water with traces of ammonia was studied in detail. The presence of glycine, alanine, alpha-amino-n-butyric acid, alpha-aminoisobutyric acid, valine, norvaline, isovaline, leucine, isoleucine, alloisoleucine, norleucine, proline, aspartic acid, glutamic acid, serine, threonine, allothreonine, alpha-hydroxy-gamma-aminobutyric acid, and alpha,gamma-diaminobutyric acid was confirmed by ion-exchange chromatography and gas chromatography-mass spectrometry. All of the primary alpha-amino acids found in the Murchison Meteorite have been synthesized by this electric discharge experiment.

Entities: Chemical

Mesh：

Substances：

Year: 1972 PMID： 4501592 PMCID： PMC426553 DOI： 10.1073/pnas.69.3.765

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

14 in total

Review 8. Understanding the Genetic Code.

Authors: Milton H Saier
Journal: J Bacteriol Date: 2019-07-10 Impact factor: 3.490

Review 9. Norvaline and norleucine may have been more abundant protein components during early stages of cell evolution.

Authors: Claudia Alvarez-Carreño; Arturo Becerra; Antonio Lazcano
Journal: Orig Life Evol Biosph Date: 2013-09-08 Impact factor: 1.950

Review 10. On the free energy that drove primordial anabolism.

Authors: Michael Kaufmann
Journal: Int J Mol Sci Date: 2009-04-22 Impact factor: 6.208

Prebiotic synthesis of hydrophobic and protein amino acids.

1. STERIC FACTORS IN THE CHEMISTRY OF POLYPEPTIDES, POLY-ALPHAAMINO ACIDS AND PROTEINS.

2. Chemical events on the primitive Earth.

3. Amino-acids, aliphatic and aromatic hydrocarbons in the Murchison Meteorite.

4. Ammonium ion concentration in the primitive ocean.

5. Shock synthesis of amino acids in simulated primitive environments.

6. Determination of N-methylamino acids and their optical purity with an amino acid analyzer.

7. Evidence for extraterrestrial amino-acids and hydrocarbons in the Murchison meteorite.

8. Prebiological protein synthesis.

9. Synthesis of amino acids by the heating of formaldehyde and ammonia.

10. Amino Acid analyses of the murchison, murray, and allende carbonaceous chondrites.

1. The spark discharge synthesis of amino acids from various hydrocarbons.

2. Amino acids in carbonaceous chondrites.

3. Origin of organic compounds on the primitive earth and in meteorites.

4. Prebiotic microreactors: a synthesis of purines and dihydroxy compounds in aqueous aerosol.

5. Self-propagating beta-sheet polypeptide structures as prebiotic informational molecular entities: the amyloid world.

6. Synthesis of β-Peptide Standards for Use in Model Prebiotic Reactions.

7. Monomer abundance distribution patterns as a universal biosignature: examples from terrestrial and digital life.

Review 8. Understanding the Genetic Code.

Review 9. Norvaline and norleucine may have been more abundant protein components during early stages of cell evolution.

Review 10. On the free energy that drove primordial anabolism.