PURPOSE: The aim of this study was to estimate inter-rater reliability and validate magnetic resonance elastography (MRE) as a tool to measure liver elasticity. MATERIALS AND METHODS: The study protocol was approved by the institutional review board at our institution. In all, 10 normal volunteers and 110 patients, who provided written informed consent, were enrolled. The pathological fibrosis score was applied as a standard reference of liver fibrosis in 21 patients. MRE was performed with a 1.5-T magnetic resonance imaging scanner with a cylindrical passive longitudinal shear wave driver placed over the right chest wall to deliver vibrations. A gradient-echo MRE sequence was used to acquire axial wave images, which were automatically converted to elastograms representing elasticity (in kilopascals, or kPa). The region of interest was placed in the right lobe of the liver on elastograms by two raters independently. To evaluate interrater reliability, the intraclass correlation coefficient was calculated. The elasticity measurements correlated with the pathological fibrosis score (F1-F4) in 21 patients. RESULTS: The intraclass correlation coefficient was almost perfect (0.993) between the elasticities measured by the two raters. The mean elasticity value for patients with F4 was 5.7 kPa; F3, 4.4 kPa; F2, 3.1 kPa; F1, 2.2 kPa; and F0, 2.1 kPa. CONCLUSION: MRE is a reliable tool to measure liver elasticity.
PURPOSE: The aim of this study was to estimate inter-rater reliability and validate magnetic resonance elastography (MRE) as a tool to measure liver elasticity. MATERIALS AND METHODS: The study protocol was approved by the institutional review board at our institution. In all, 10 normal volunteers and 110 patients, who provided written informed consent, were enrolled. The pathological fibrosis score was applied as a standard reference of liver fibrosis in 21 patients. MRE was performed with a 1.5-T magnetic resonance imaging scanner with a cylindrical passive longitudinal shear wave driver placed over the right chest wall to deliver vibrations. A gradient-echo MRE sequence was used to acquire axial wave images, which were automatically converted to elastograms representing elasticity (in kilopascals, or kPa). The region of interest was placed in the right lobe of the liver on elastograms by two raters independently. To evaluate interrater reliability, the intraclass correlation coefficient was calculated. The elasticity measurements correlated with the pathological fibrosis score (F1-F4) in 21 patients. RESULTS: The intraclass correlation coefficient was almost perfect (0.993) between the elasticities measured by the two raters. The mean elasticity value for patients with F4 was 5.7 kPa; F3, 4.4 kPa; F2, 3.1 kPa; F1, 2.2 kPa; and F0, 2.1 kPa. CONCLUSION: MRE is a reliable tool to measure liver elasticity.
Authors: Laurent Huwart; Christine Sempoux; Eric Vicaut; Najat Salameh; Laurence Annet; Etienne Danse; Frank Peeters; Leon C ter Beek; Jacques Rahier; Ralph Sinkus; Yves Horsmans; Bernard E Van Beers Journal: Gastroenterology Date: 2008-04-04 Impact factor: 22.682
Authors: A Manduca; T E Oliphant; M A Dresner; J L Mahowald; S A Kruse; E Amromin; J P Felmlee; J F Greenleaf; R L Ehman Journal: Med Image Anal Date: 2001-12 Impact factor: 8.545
Authors: Jignesh Patel; Eric E Sigmund; Henry Rusinek; Marcel Oei; James S Babb; Bachir Taouli Journal: J Magn Reson Imaging Date: 2010-03 Impact factor: 4.813
Authors: Olivier Rouvière; Meng Yin; M Alex Dresner; Phillip J Rossman; Lawrence J Burgart; Jeff L Fidler; Richard L Ehman Journal: Radiology Date: 2006-08 Impact factor: 11.105
Authors: H Tsukuma; T Hiyama; S Tanaka; M Nakao; T Yabuuchi; T Kitamura; K Nakanishi; I Fujimoto; A Inoue; H Yamazaki Journal: N Engl J Med Date: 1993-06-24 Impact factor: 91.245
Authors: Meng Yin; Jayant A Talwalkar; Kevin J Glaser; Armando Manduca; Roger C Grimm; Phillip J Rossman; Jeff L Fidler; Richard L Ehman Journal: Clin Gastroenterol Hepatol Date: 2007-10 Impact factor: 11.382
Authors: Sudhakar K Venkatesh; Meng Yin; James F Glockner; Naoki Takahashi; Philip A Araoz; Jayant A Talwalkar; Richard L Ehman Journal: AJR Am J Roentgenol Date: 2008-06 Impact factor: 3.959
Authors: Jayant A Talwalkar; Meng Yin; Sudhakar Venkatesh; Phillip J Rossman; Roger C Grimm; Armando Manduca; Anthony Romano; Patrick S Kamath; Richard L Ehman Journal: AJR Am J Roentgenol Date: 2009-07 Impact factor: 3.959