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Literature DB >> 20960230

The flow synthesis of heterocycles for natural product and medicinal chemistry applications.

Marcus Baumann¹, Ian R Baxendale, Steven V Ley.

Abstract

This article represents an overview of recent research from the Innovative Technology Centre in the field of flow chemistry which was presented at the FROST2 meeting in Budapest in October 2009. After a short introduction of this rapidly expanding field, we discuss some of our results with a main focus on the synthesis of heterocyclic compounds which we use in various natural product and medicinal chemistry programmes.

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Year: 2010 PMID： 20960230 DOI： 10.1007/s11030-010-9282-1

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943

49 in total

1. Asymmetric catalysis on sequentially-linked columns.

Authors: A M Hafez; A E Taggi; T Dudding; T Lectka
Journal: J Am Chem Soc Date: 2001-11-07 Impact factor: 15.419

2. Perfluoroalkylation with Organosilicon Reagents.

Authors: G. K. Surya Prakash; Andrei K. Yudin
Journal: Chem Rev Date: 1997-05-08 Impact factor: 60.622

3. Asymmetric Diels-Alder Reaction of Methacrolein with Cyclopentadiene Using Polymer-Supported Catalysts: Design of Highly Enantioselective Polymeric Catalysts.

Authors: Koichi Kamahori; Koichi Ito; Shinichi Itsuno
Journal: J Org Chem Date: 1996-11-15 Impact factor: 4.354

4. Combining enabling techniques in organic synthesis: continuous flow processes with heterogenized catalysts.

Authors: Andreas Kirschning; Wladimir Solodenko; Klaas Mennecke
Journal: Chemistry Date: 2006-08-07 Impact factor: 5.236

5. Integrated continuous microfluidic liquid-liquid extraction.

Authors: Jason G Kralj; Hemantkumar R Sahoo; Klavs F Jensen
Journal: Lab Chip Date: 2006-10-24 Impact factor: 6.799

6. Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor.

Authors: Laia Malet-Sanz; Julia Madrzak; Steven V Ley; Ian R Baxendale
Journal: Org Biomol Chem Date: 2010-09-27 Impact factor: 3.876

7. Group efficiency: a guideline for hits-to-leads chemistry.

Authors: Marcel L Verdonk; David C Rees
Journal: ChemMedChem Date: 2008-08 Impact factor: 3.466

8. Organic synthesis: Scavengers in full flow.

Authors: Peter H Seeberger
Journal: Nat Chem Date: 2009-07 Impact factor: 24.427

9. The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines.

Authors: Steen Saaby; Kristian Rahbek Knudsen; Mark Ladlow; Steven V Ley
Journal: Chem Commun (Camb) Date: 2005-06-21 Impact factor: 6.222

The flow synthesis of heterocycles for natural product and medicinal chemistry applications.

1. Asymmetric catalysis on sequentially-linked columns.

2. Perfluoroalkylation with Organosilicon Reagents.

3. Asymmetric Diels-Alder Reaction of Methacrolein with Cyclopentadiene Using Polymer-Supported Catalysts: Design of Highly Enantioselective Polymeric Catalysts.

4. Combining enabling techniques in organic synthesis: continuous flow processes with heterogenized catalysts.

5. Integrated continuous microfluidic liquid-liquid extraction.

6. Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor.

7. Group efficiency: a guideline for hits-to-leads chemistry.

8. Organic synthesis: Scavengers in full flow.

9. The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines.

10. Rapid multistep synthesis of 1,2,4-oxadiazoles in a single continuous microreactor sequence.

1. HPLC-assisted automated oligosaccharide synthesis.

2. C-O bond Formation in a Microfluidic Reactor: High Yield S_NAr Substitution of Heteroaryl Chlorides.

3. The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors.

Review 4. The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry.

5. Efficient amide bond formation through a rapid and strong activation of carboxylic acids in a microflow reactor.

Review 6. Continuous-flow processes for the catalytic partial hydrogenation reaction of alkynes.

7. Camera-enabled techniques for organic synthesis.

8. The rapid generation of isothiocyanates in flow.

9. Micro-flow synthesis and structural analysis of sterically crowded diimine ligands with five aryl rings.

10. Exploring Flow Procedures for Diazonium Formation.