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Literature DB >> 15957022

The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines.

Steen Saaby¹, Kristian Rahbek Knudsen, Mark Ladlow, Steven V Ley.

Abstract

Imines have been reduced to amines in high yield, and with excellent chemoselectivity, by catalytic hydrogenation in a continuous flow-reactor, utilising an electrochemically-generated hydrogen source to produce a mixed hydrogen-liquid flow stream.

Entities: Chemical

Mesh：

Substances：
Amines
Imines
Hydrogen

Year: 2005 PMID： 15957022 DOI： 10.1039/b504854k

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

13 in total

1. The flow synthesis of heterocycles for natural product and medicinal chemistry applications.

Authors: Marcus Baumann; Ian R Baxendale; Steven V Ley
Journal: Mol Divers Date: 2010-10-20 Impact factor: 2.943

Review 2. Automating drug discovery.

Authors: Gisbert Schneider
Journal: Nat Rev Drug Discov Date: 2017-12-15 Impact factor: 84.694

3. Ligand-accelerated cross-coupling of C(sp2)-H bonds with arylboron reagents.

Authors: Keary M Engle; Peter S Thuy-Boun; Michael Dang; Jin-Quan Yu
Journal: J Am Chem Soc Date: 2011-10-21 Impact factor: 15.419

4. Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups.

Authors: Julien Rolland; Xacobe C Cambeiro; Carles Rodríguez-Escrich; Miquel A Pericàs
Journal: Beilstein J Org Chem Date: 2009-10-15 Impact factor: 2.883

5. A new palladium-mediated approach to 4-N-arylamino-1-butanols from peroxidic tetrahydrofuran and primary aromatic amines.

Authors: Henry F Russell; John B Bremner; Jennifer Bushelle-Edghill; Melissa R Lewis; Stacey R Thomas; Floyd Bates
Journal: Tetrahedron Lett Date: 2007-02-26 Impact factor: 2.415

The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines.

1. The flow synthesis of heterocycles for natural product and medicinal chemistry applications.

Review 2. Automating drug discovery.

3. Ligand-accelerated cross-coupling of C(sp2)-H bonds with arylboron reagents.

4. Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups.

5. A new palladium-mediated approach to 4-N-arylamino-1-butanols from peroxidic tetrahydrofuran and primary aromatic amines.

6. Heterogeneously Catalyzed Continuous-Flow Hydrogenation Using Segmented Flow in Capillary Columns.

7. Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis.

8. Continuous flow hydrogenation using polysilane-supported palladium/alumina hybrid catalysts.

9. Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide.

10. Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry.