Literature DB >> 20956080

The expanding role of marine microbes in pharmaceutical development.

Amanda L Waters1, Russell T Hill, Allen R Place, Mark T Hamann.   

Abstract

Marine microbes have received growing attention as sources of bioactive metabolites and offer a unique opportunity to both increase the number of marine natural products in clinical trials as well as expedite their development. This review focuses specifically on those molecules currently in the clinical pipeline that are established or highly likely to be produced by bacteria based on expanding circumstantial evidence. We also include an example of how compounds from harmful algal blooms may yield both tools for measuring environmental change as well as leads for pharmaceutical development. An example of the karlotoxin class of compounds isolated from the dinoflagellate Karlodinium veneficum reveals a significant environmental impact in the form of massive fish kills, but also provides opportunities to construct new molecules for the control of cancer and serum cholesterol assisted by tools associated with rational drug design.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20956080      PMCID： PMC2994104          DOI： 10.1016/j.copbio.2010.09.013

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  44 in total

1.  Microbial and chemical conversion of antibiotic K41. II. Preparation of K41-DA1, -DA2 and -DA3 deamicetosyl derivatives of antibiotic K41.

Authors:  M Hoshi; T Endo
Journal:  J Antibiot (Tokyo)       Date:  2000-10       Impact factor: 2.649

2.  Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

Authors:  Robert H Feling; Greg O Buchanan; Tracy J Mincer; Christopher A Kauffman; Paul R Jensen; William Fenical
Journal:  Angew Chem Int Ed Engl       Date:  2003-01-20       Impact factor: 15.336

Review 3.  Cholesterol, lipid rafts, and disease.

Authors:  Kai Simons; Robert Ehehalt
Journal:  J Clin Invest       Date:  2002-09       Impact factor: 14.808

4.  Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.

Authors:  H Luesch; R E Moore; V J Paul; S L Mooberry; T H Corbett
Journal:  J Nat Prod       Date:  2001-07       Impact factor: 4.050

5.  A phase I study of the dolastatin-15 analogue tasidotin (ILX651) administered intravenously daily for 5 consecutive days every 3 weeks in patients with advanced solid tumors.

Authors:  Scot Ebbinghaus; Eric Rubin; Evan Hersh; Lee D Cranmer; Peter L Bonate; Robert J Fram; Antti Jekunen; Steve Weitman; Lisa A Hammond
Journal:  Clin Cancer Res       Date:  2005-11-01       Impact factor: 12.531

6.  Antitumor activity of phenylahistin in vitro and in vivo.

Authors:  K Kanoh; S Kohno; J Katada; Y Hayashi; M Muramatsu; I Uno
Journal:  Biosci Biotechnol Biochem       Date:  1999-06       Impact factor: 2.043

7.  Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B.

Authors:  C Cuevas; M Pérez; M J Martín; J L Chicharro; C Fernández-Rivas; M Flores; A Francesch; P Gallego; M Zarzuelo; F de La Calle; J García; C Polanco; I Rodríguez; I Manzanares
Journal:  Org Lett       Date:  2000-08-10       Impact factor: 6.005

8.  Evidence for the biosynthesis of bryostatins by the bacterial symbiont "Candidatus Endobugula sertula" of the bryozoan Bugula neritina.

Authors:  S K Davidson; S W Allen; G E Lim; C M Anderson; M G Haygood
Journal:  Appl Environ Microbiol       Date:  2001-10       Impact factor: 4.792

9.  Serum lipid concentrations in obsessive-compulsive disorder patients with and without panic attacks.

Authors:  Mehmet Yucel Agargun; Haluk Dulger; Rifat Inci; Hayrettin Kara; Omer Akil Ozer; Mehmet Ramazan Sekeroglu; Lutfullah Besiroglu
Journal:  Can J Psychiatry       Date:  2004-11       Impact factor: 4.356

Review 10.  Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases.

Authors:  Jacques Fantini; Nicolas Garmy; Radhia Mahfoud; Nouara Yahi
Journal:  Expert Rev Mol Med       Date:  2002-12-20       Impact factor: 5.600
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  36 in total

1.  Computational modeling of culture media for enhanced production of fibrinolytic enzyme from marine bacterium Fictibacillus sp. strain SKA27 and in vitro evaluation of fibrinolytic activity.

Authors:  K Joji; A Santhiagu; Nisha Salim
Journal:  3 Biotech       Date:  2019-08-06       Impact factor: 2.406

2.  Optimization of the culture condition for an antitumor bacterium Serratia proteamacula 657 and identification of the active compounds.

Authors:  Li Miao; Xueling Wang; Wei Jiang; Shengping Yang; Huiru Zhou; Youpeng Zhai; Xiaojian Zhou; Kunming Dong
Journal:  World J Microbiol Biotechnol       Date:  2012-12-28       Impact factor: 3.312

3.  Two new karlotoxins found in Karlodinium veneficum (strain GM2) from the East China Sea.

Authors:  Pengjie Cai; Shan He; Chengxu Zhou; Allen R Place; Saddef Haq; Lijian Ding; Haimin Chen; Ying Jiang; Cheng Guo; Yaru Xu; Jinrong Zhang; Xiaojun Yan
Journal:  Harmful Algae       Date:  2016-08-27       Impact factor: 4.273

Review 4.  Microtubule drugs: action, selectivity, and resistance across the kingdoms of life.

Authors:  V Dostál; L Libusová
Journal:  Protoplasma       Date:  2014-03-21       Impact factor: 3.356

Review 5.  Marine natural product peptides with therapeutic potential: Chemistry, biosynthesis, and pharmacology.

Authors:  Vedanjali Gogineni; Mark T Hamann
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-08-24       Impact factor: 3.770

6.  Draft genome sequence of marine-derived Streptomyces sp. strain AA0539, isolated from the Yellow Sea, China.

Authors:  Zhi-Qiang Xiong; Yong Wang
Journal:  J Bacteriol       Date:  2012-12       Impact factor: 3.490

7.  The Marine Dinoflagellate Alexandrium andersoni Induces Cell Death in Lung and Colorectal Tumor Cell Lines.

Authors:  Clementina Sansone; Genoveffa Nuzzo; Christian Galasso; Raffaella Casotti; Angelo Fontana; Giovanna Romano; Adrianna Ianora
Journal:  Mar Biotechnol (NY)       Date:  2018-04-20       Impact factor: 3.619

Review 8.  Natural products: a continuing source of novel drug leads.

Authors:  Gordon M Cragg; David J Newman
Journal:  Biochim Biophys Acta       Date:  2013-02-18

Review 9.  Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage.

Authors:  Patrick C Still; Tyler A Johnson; Christine M Theodore; Steven T Loveridge; Phillip Crews
Journal:  J Nat Prod       Date:  2014-02-26       Impact factor: 4.050

10.  Stereochemical Studies of the Karlotoxin Class Using NMR Spectroscopy and DP4 Chemical-Shift Analysis: Insights into their Mechanism of Action.

Authors:  Amanda L Waters; Joonseok Oh; Allen R Place; Mark T Hamann
Journal:  Angew Chem Int Ed Engl       Date:  2015-11-16       Impact factor: 15.336
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