Microbial and chemical conversion of antibiotic K41. II. Preparation of K41-DA1, -DA2 and -DA3 deamicetosyl derivatives of antibiotic K41.

Antibiotic derivative K41-DA1, -DA2 and -DA3 (2 approximately 4), deamicetosyl derivatives of antibiotic K41 (1), were prepared by acidic degradation of K41 and following hydrogenation reaction. K41-DA2 (3) showed comparable antimicrobial activities to K41 in vitro but not in vivo.