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Literature DB >> 20936100

Novel neoclerodane diterpene derivatives from the smoke of salvinorin A.

Abstract

Salvinorin A is a naturally-occurring potent and selective kappa opioid receptor agonist, and smoking salvinorin A produces the most intense hallucinogenic effects in human. Eight neoclerodane diterpene derivatives were isolated from the smoke of salvinorin A, and their structures were identified by spectroscopic methods. The major structural changes include epimerizations, eliminations, and rearrangements.

Entities: Chemical Disease Gene Species

Year: 2010 PMID： 20936100 PMCID： PMC2950941 DOI： 10.1016/j.tetlet.2010.07.144

Source DB: PubMed Journal: Tetrahedron Lett ISSN： 0040-4039 Impact factor: 2.415

14 in total

Review 1. Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor.

Authors: Douglas J Sheffler; Bryan L Roth
Journal: Trends Pharmacol Sci Date: 2003-03 Impact factor: 14.819

2. Pattern of use and subjective effects of Salvia divinorum among recreational users.

Authors: Débora González; Jordi Riba; José Carlos Bouso; Gregorio Gómez-Jarabo; Manel J Barbanoj
Journal: Drug Alcohol Depend Date: 2006-05-23 Impact factor: 4.492

3. Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18).

Authors: Cécile Béguin; Michele R Richards; Jian-Guo Li; Yulin Wang; Wei Xu; Lee-Yuan Liu-Chen; William A Carlezon; Bruce M Cohen
Journal: Bioorg Med Chem Lett Date: 2006-06-13 Impact factor: 2.823

4. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A.

Authors: Wayne W Harding; Matthew Schmidt; Kevin Tidgewell; Pavitra Kannan; Kenneth G Holden; Brian Gilmour; Hernan Navarro; Richard B Rothman; Thomas E Prisinzano
Journal: J Nat Prod Date: 2006-01 Impact factor: 4.050

Novel neoclerodane diterpene derivatives from the smoke of salvinorin A.

Review 1. Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor.

2. Pattern of use and subjective effects of Salvia divinorum among recreational users.

3. Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18).

4. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A.

5. Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum.

6. Revised structure of deacetyl-1,10-didehydrosalvinorin G.

7. A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2-2H3]-salvinorin A.

8. Synthesis of deacetyl-1,10-didehydrosalvinorin G.

Review 9. Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuse.

10. Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.

Review 1. Clerodane diterpenes: sources, structures, and biological activities.

Review 2. Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A.

Review 3. A review of salvinorin analogs and their kappa-opioid receptor activity.

4. Palladium-catalyzed transformations of salvinorin A, a neoclerodane diterpene from Salvia divinorum.