Literature DB >> 29615341

A review of salvinorin analogs and their kappa-opioid receptor activity.

Jeremy J Roach1, Ryan A Shenvi2.   

Abstract

The plant metabolite salvinorin A potently and selectively agonizes the human kappa-opioid receptor, an emerging target for next-generation analgesics. Here we review analogs of the salvinorin chemotype and their effects on selectivity, affinity and potency. Extensive peripheral modifications using isolated salvinorin A have delivered a trove of SAR information. More deep-seated changes are now possible by advances in chemical synthesis.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  GPCR; Kappa-opioid; Opioid; Salvinorin; Terpenoid

Mesh：

Substances：

Year:  2018        PMID： 29615341      PMCID： PMC5912166          DOI： 10.1016/j.bmcl.2018.03.029

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  80 in total

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4.  Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues.

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7.  Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability.

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8.  Synthesis and biological evaluation of C-2 halogenated analogs of salvinorin A.

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Review 7.  Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects.

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