Literature DB >> 19099466

Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuse.

Thomas E Prisinzano1.   

Abstract

Much of what we know about the neurosciences is the direct result of studying psychoactive natural products. Unfortunately, there are many gaps in our understanding of the basic biological processes that contribute to the etiology of many CNS disorders. The investigation of psychoactive natural products offers an excellent approach to identify novel agents to treat CNS disorders and to find new chemical tools to better elucidate their biological mechanisms. This review will detail recent progress in a program directed toward investigating psychoactive natural products with the goal of treating drug abuse by targeting kappa opioid receptors.

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Year:  2009        PMID： 19099466      PMCID： PMC2788013          DOI： 10.1021/np8005748

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  150 in total

Review 1.  Possible pharmacotherapy of the opioid kappa receptor agonist for drug dependence.

Authors:  Ko Hasebe; Koji Kawai; Tomohiko Suzuki; Kuniaki Kawamura; Toshiaki Tanaka; Minoru Narita; Hiroshi Nagase; Tsutomu Suzuki
Journal:  Ann N Y Acad Sci       Date:  2004-10       Impact factor: 5.691

Review 2.  Receptor-mediated calcium entry.

Authors:  T J Rink
Journal:  FEBS Lett       Date:  1990-08-01       Impact factor: 4.124

3.  Enhanced morphine analgesia in mice lacking beta-arrestin 2.

Authors:  L M Bohn; R J Lefkowitz; R R Gainetdinov; K Peppel; M G Caron; F T Lin
Journal:  Science       Date:  1999-12-24       Impact factor: 47.728

4.  Kappa opioid inhibition of morphine and cocaine self-administration in rats.

Authors:  S D Glick; I M Maisonneuve; J Raucci; S Archer
Journal:  Brain Res       Date:  1995-05-29       Impact factor: 3.252

Review 5.  Cocaine addiction: psychology and neurophysiology.

Authors:  F H Gawin
Journal:  Science       Date:  1991-03-29       Impact factor: 47.728

6.  Morphine side effects in beta-arrestin 2 knockout mice.

Authors:  Kirsten M Raehal; Julia K L Walker; Laura M Bohn
Journal:  J Pharmacol Exp Ther       Date:  2005-05-25       Impact factor: 4.030

7.  Effects of JDTic, a selective kappa-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model.

Authors:  F Ivy Carroll; Louis S Harris; Mario D Aceto
Journal:  Eur J Pharmacol       Date:  2005-10-19       Impact factor: 4.432

8.  Hepatotoxicity of germander (Teucrium chamaedrys L.) and one of its constituent neoclerodane diterpenes teucrin A in the mouse.

Authors:  S A Kouzi; R J McMurtry; S D Nelson
Journal:  Chem Res Toxicol       Date:  1994 Nov-Dec       Impact factor: 3.739

9.  Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A.

Authors:  Thomas A Munro; Mark A Rizzacasa
Journal:  J Nat Prod       Date:  2003-05       Impact factor: 4.050

10.  Evaluation of no-wash calcium assay kits: enabling tools for calcium mobilization.

Authors:  Hong Xin; Yuanping Wang; Matthew J Todd; Jianshen Qi; Lisa K Minor
Journal:  J Biomol Screen       Date:  2007-05-30
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  17 in total

1.  Targeting and extending the eukaryotic druggable genome with natural products.

Authors:  Hendrik Luesch; John B MacMillan
Journal:  Nat Prod Rep       Date:  2020-06-24       Impact factor: 13.423

2.  Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence.

Authors:  Jacob M Hooker; Thomas A Munro; Cécile Béguin; David Alexoff; Colleen Shea; Youwen Xu; Bruce M Cohen
Journal:  Neuropharmacology       Date:  2009-07-08       Impact factor: 5.250

3.  Exploration of cascade cyclizations terminated by tandem aromatic substitution: total synthesis of (+)-schweinfurthin A.

Authors:  Joseph J Topczewski; John G Kodet; David F Wiemer
Journal:  J Org Chem       Date:  2011-01-12       Impact factor: 4.354

Review 4.  Salvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse.

Authors:  Bronwyn M Kivell; Amy W M Ewald; Thomas E Prisinzano
Journal:  Adv Pharmacol       Date:  2014

5.  Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine.

Authors:  Richard W Fitch; Barry B Snider; Quan Zhou; Bruce M Foxman; Anshul A Pandya; Jerrel L Yakel; Thao T Olson; Nour Al-Muhtasib; Yingxian Xiao; Kevin D Welch; Kip E Panter
Journal:  J Nat Prod       Date:  2018-04-19       Impact factor: 4.050

6.  Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.

Authors:  András Váradi; Gina F Marrone; Travis C Palmer; Ankita Narayan; Márton R Szabó; Valerie Le Rouzic; Steven G Grinnell; Joan J Subrath; Evelyn Warner; Sanjay Kalra; Amanda Hunkele; Jeremy Pagirsky; Shainnel O Eans; Jessica M Medina; Jin Xu; Ying-Xian Pan; Attila Borics; Gavril W Pasternak; Jay P McLaughlin; Susruta Majumdar
Journal:  J Med Chem       Date:  2016-09-02       Impact factor: 7.446

7.  Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability.

Authors:  Alexander M Sherwood; Rachel Saylor Crowley; Kelly F Paton; Andrew Biggerstaff; Benjamin Neuenswander; Victor W Day; Bronwyn M Kivell; Thomas E Prisinzano
Journal:  J Med Chem       Date:  2017-04-19       Impact factor: 7.446

8.  Novel neoclerodane diterpene derivatives from the smoke of salvinorin A.

Authors:  Zhongze Ma; Gang Deng; David Y W Lee
Journal:  Tetrahedron Lett       Date:  2010-09-29       Impact factor: 2.415

9.  5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.

Authors:  Dwight A Williams; Saheem A Zaidi; Yan Zhang
Journal:  Bioorg Med Chem Lett       Date:  2014-02-19       Impact factor: 2.823

10.  Synthetic studies of neoclerodane diterpenes from Salvia divinorum: role of the furan in affinity for opioid receptors.

Authors:  Denise S Simpson; Kimberly M Lovell; Anthony Lozama; Nina Han; Victor W Day; Christina M Dersch; Richard B Rothman; Thomas E Prisinzano
Journal:  Org Biomol Chem       Date:  2009-07-14       Impact factor: 3.876
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