| Literature DB >> 20934516 |
Mercedes E Arana1, Thomas A Kunkel.
Abstract
This article considers the fidelity of DNA replication performed by eukaryotic DNA polymerases involved in replicating the nuclear genome. DNA replication fidelity can vary widely depending on the DNA polymerase, the composition of the error, the flanking sequence, the presence of DNA damage and the ability to correct errors. As a consequence, defects in processes that determine DNA replication fidelity can confer strong mutator phenotypes whose specificity can help determine the molecular nature of the defect. Published by Elsevier Ltd.Entities:
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Year: 2010 PMID： 20934516 PMCID： PMC3087159 DOI： 10.1016/j.semcancer.2010.10.003
Source DB: PubMed Journal: Semin Cancer Biol ISSN： 1044-579X Impact factor: 15.707