Literature DB >> 20853833

A responsive europium(III) chelate that provides a direct readout of pH by MRI.

Yunkou Wu1, Todd C Soesbe, Garry E Kiefer, Piyu Zhao, A Dean Sherry.   

Abstract

A europium(III) DO3A-tris(amide) complex is reported for imaging pH by MRI using ratiometric chemical exchange saturation transfer (CEST) principles. Deprotonation of a single phenolic proton between pH 6 and 7.6 results in an ∼5 ppm shift in the water exchange CEST peak that is easily detected by MRI. Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker.

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Year:  2010        PMID： 20853833      PMCID： PMC2951490          DOI： 10.1021/ja106018n

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  16 in total

1.  MRI thermometry based on PARACEST agents.

Authors:  Shanrong Zhang; Craig R Malloy; A Dean Sherry
Journal:  J Am Chem Soc       Date:  2005-12-21       Impact factor: 15.419

2.  Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI.

Authors:  Donald E Woessner; Shanrong Zhang; Matthew E Merritt; A Dean Sherry
Journal:  Magn Reson Med       Date:  2005-04       Impact factor: 4.668

Review 3.  Chemical exchange saturation transfer contrast agents for magnetic resonance imaging.

Authors:  A Dean Sherry; Mark Woods
Journal:  Annu Rev Biomed Eng       Date:  2008       Impact factor: 9.590

4.  Detection of enzymatic activity by PARACEST MRI: a general approach to target a large variety of enzymes.

Authors:  Thomas Chauvin; Philippe Durand; Michèle Bernier; Hervé Meudal; Bich-Thuy Doan; Fanny Noury; Bernard Badet; Jean-Claude Beloeil; Eva Tóth
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

5.  A PARACEST MRI contrast agent to detect enzyme activity.

Authors:  Byunghee Yoo; Marty D Pagel
Journal:  J Am Chem Soc       Date:  2006-11-01       Impact factor: 15.419

6.  A paramagnetic CEST agent for imaging glucose by MRI.

Authors:  Shanrong Zhang; Robert Trokowski; A Dean Sherry
Journal:  J Am Chem Soc       Date:  2003-12-17       Impact factor: 15.419

7.  Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects.

Authors:  S James Ratnakar; Mark Woods; Angelo J M Lubag; Zoltan Kovacs; A Dean Sherry
Journal:  J Am Chem Soc       Date:  2007-12-08       Impact factor: 15.419

8.  A PARACEST agent responsive to inner- and outer-sphere phosphate ester interactions for MRI applications.

Authors:  Ching-Hui Huang; Janet R Morrow
Journal:  J Am Chem Soc       Date:  2009-04-01       Impact factor: 15.419

9.  Design and characterization of a new irreversible responsive PARACEST MRI contrast agent that detects nitric oxide.

Authors:  Guanshu Liu; Yuguo Li; Mark D Pagel
Journal:  Magn Reson Med       Date:  2007-12       Impact factor: 4.668

10.  Dendritic PARACEST contrast agents for magnetic resonance imaging.

Authors:  J A Pikkemaat; R T Wegh; R Lamerichs; R A van de Molengraaf; S Langereis; D Burdinski; A Y F Raymond; H M Janssen; B F M de Waal; N P Willard; E W Meijer; H Grüll
Journal:  Contrast Media Mol Imaging       Date:  2007 Sep-Oct       Impact factor: 3.161
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  40 in total

1.  The pH sensitivity of -NH exchange in LnDOTA-tetraamide complexes varies with amide substituent.

Authors:  Ana Christina L Opina; Yunkou Wu; Piyu Zhao; Garry Kiefer; A Dean Sherry
Journal:  Contrast Media Mol Imaging       Date:  2011 Nov-Dec       Impact factor: 3.161

Review 2.  Is there a path beyond BOLD? Molecular imaging of brain function.

Authors:  Alan P Koretsky
Journal:  Neuroimage       Date:  2012-03-03       Impact factor: 6.556

Review 3.  Lanthanide probes for bioresponsive imaging.

Authors:  Marie C Heffern; Lauren M Matosziuk; Thomas J Meade
Journal:  Chem Rev       Date:  2013-12-13       Impact factor: 60.622

4.  pH imaging of mouse kidneys in vivo using a frequency-dependent paraCEST agent.

Authors:  Yunkou Wu; Shanrong Zhang; Todd C Soesbe; Jing Yu; Elena Vinogradov; Robert E Lenkinski; A Dean Sherry
Journal:  Magn Reson Med       Date:  2015-07-14       Impact factor: 4.668

5.  A Frequency-Selective pH-Responsive paraCEST Agent.

Authors:  S James Ratnakar; Sara Chirayil; Alexander M Funk; Shanrong Zhang; João F Queiró; Carlos F G C Geraldes; Zoltan Kovacs; A Dean Sherry
Journal:  Angew Chem Int Ed Engl       Date:  2020-10-06       Impact factor: 15.336

6.  Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept.

Authors:  Dario Livio Longo; Pietro Irrera; Lorena Consolino; Phillip Zhe Sun; Michael T McMahon
Journal:  Methods Mol Biol       Date:  2021

Review 7.  Advantages of paramagnetic chemical exchange saturation transfer (CEST) complexes having slow to intermediate water exchange properties as responsive MRI agents.

Authors:  Todd C Soesbe; Yunkou Wu; A Dean Sherry
Journal:  NMR Biomed       Date:  2012-10-11       Impact factor: 4.044

8.  CEST phase mapping using a length and offset varied saturation (LOVARS) scheme.

Authors:  Xiaolei Song; Assaf A Gilad; Suresh Joel; Guanshu Liu; Amnon Bar-Shir; Yajie Liang; Michael Gorelik; James J Pekar; Peter C M van Zijl; Jeff W M Bulte; Michael T McMahon
Journal:  Magn Reson Med       Date:  2012-01-13       Impact factor: 4.668

9.  Gd-labeled glycol chitosan as a pH-responsive magnetic resonance imaging agent for detecting acidic tumor microenvironments.

Authors:  Kido Nwe; Ching-Hui Huang; Andrew Tsourkas
Journal:  J Med Chem       Date:  2013-10-03       Impact factor: 7.446

Review 10.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
Journal:  Chem Rev       Date:  2018-10-16       Impact factor: 60.622
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