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Literature DB >> 20728581

Age effects on B cells and humoral immunity in humans.

Daniela Frasca¹, Alain Diaz, Maria Romero, Ana Marie Landin, Bonnie B Blomberg.

Abstract

Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2010 PMID： 20728581 PMCID： PMC3040253 DOI： 10.1016/j.arr.2010.08.004

Source DB: PubMed Journal: Ageing Res Rev ISSN： 1568-1637 Impact factor: 10.895

69 in total

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Review 5. AID in somatic hypermutation and class switch recombination.

Authors: Simonne Longerich; Uttiya Basu; Frederick Alt; Ursula Storb
Journal: Curr Opin Immunol Date: 2006-02-07 Impact factor: 7.486

Review 6. Aging of the immune system as a prognostic factor for human longevity.

Authors: Anis Larbi; Claudio Franceschi; Dawn Mazzatti; Rafael Solana; Anders Wikby; Graham Pawelec
Journal: Physiology (Bethesda) Date: 2008-04

Review 7. Immunosenescence and vaccine failure in the elderly.

Authors: Beatrix Grubeck-Loebenstein; Silvia Della Bella; Anna Maria Iorio; Jean-Pierre Michel; Graham Pawelec; Rafael Solana
Journal: Aging Clin Exp Res Date: 2009-06 Impact factor: 3.636

Review 8. CD28 extinction in human T cells: altered functions and the program of T-cell senescence.

Authors: Abbe N Vallejo
Journal: Immunol Rev Date: 2005-06 Impact factor: 12.988

9. Immunoglobulin patterns in humans over 95 years of age.

Authors: J Radl; J M Sepers; F Skvaril; A Morell; W Hijmans
Journal: Clin Exp Immunol Date: 1975-10 Impact factor: 4.330

Review 10. Human IgM+CD27+ B cells: memory B cells or "memory" B cells?

Authors: Stuart G Tangye; Kim L Good
Journal: J Immunol Date: 2007-07-01 Impact factor: 5.422

93 in total

1. Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine.

Authors: Daniela Frasca; Alain Diaz; Maria Romero; Mitch Phillips; Nicholas V Mendez; Ana Marie Landin; Bonnie B Blomberg
Journal: Int Immunol Date: 2012-01-25 Impact factor: 4.823

2. Integration of immunity with physical and cognitive function in definitions of successful aging.

Authors: Patricia Griffin; Joshua J Michel; Kristy Huysman; Alison J Logar; Abbe N Vallejo
Journal: Aging Dis Date: 2012-02-27 Impact factor: 6.745

Review 3. Reversing T cell immunosenescence: why, who, and how.

Authors: Pierre Olivier Lang; Sheila Govind; Richard Aspinall
Journal: Age (Dordr) Date: 2012-02-26

4. Immune aging and challenges for immune protection of the graying population.

Authors: Abbe N Vallejo
Journal: Aging Dis Date: 2011-10-28 Impact factor: 6.745

5. Effects of aging on human leukocytes (part II): immunophenotyping of adaptive immune B and T cell subsets.

Authors: Ulrik Stervbo; Cecilia Bozzetti; Udo Baron; Karsten Jürchott; Sarah Meier; Julia Nora Mälzer; Mikalai Nienen; Sven Olek; Dominika Rachwalik; Axel Ronald Schulz; Avidan Neumann; Nina Babel; Andreas Grützkau; Andreas Thiel
Journal: Age (Dordr) Date: 2015-09-02

Review 6. The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.

Authors: Janet E McElhaney; Xin Zhou; H Keipp Talbot; Ernst Soethout; R Chris Bleackley; David J Granville; Graham Pawelec
Journal: Vaccine Date: 2012-01-27 Impact factor: 3.641