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Literature DB >> 1424294

Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population.

R Paganelli¹, I Quinti, U Fagiolo, A Cossarizza, C Ortolani, E Guerra, P Sansoni, L P Pucillo, E Scala, E Cozzi.

Abstract

The study of 87 adults of different ages, including 15 centenarians, selected for their healthy status, showed that profound changes of humoral immunity occur throughout life. In particular, a statistically significant age-related increase of the serum level of immunoglobulin classes (IgG and IgA but not IgM) and IgG subclasses (IgG1, 2 and 3, but not IgG4) was detected. A parallel age-related decrease of circulating B cells was also observed. The hypothesis of a complex derangement of B cell function and/or compartmentalization with age is put forward, together with the proposal that healthy centenarians (as representative of successful ageing) may be helpful in identifying the physiological age-related modifications of the immune system.

Entities: Gene

Mesh：

Substances：
Immunoglobulin Isotypes

Year: 1992 PMID： 1424294 PMCID： PMC1554614 DOI： 10.1111/j.1365-2249.1992.tb07954.x

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

21 in total

1. Response to oligosaccharide-protein conjugate vaccine against Hemophilus influenzae b in two patients with IgG2 deficiency unresponsive to capsular polysaccharide vaccine.

Authors: R A Insel; P W Anderson
Journal: N Engl J Med Date: 1986-08-21 Impact factor: 91.245

Review 7. Effects of aging on B cell function.

Authors: Daniela Frasca; Bonnie B Blomberg
Journal: Curr Opin Immunol Date: 2009-07-14 Impact factor: 7.486

Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population.

1. Response to oligosaccharide-protein conjugate vaccine against Hemophilus influenzae b in two patients with IgG2 deficiency unresponsive to capsular polysaccharide vaccine.

2. Thymic hormone deficiency in normal ageing and Down's syndrome: is there a primary failure of the thymus?

3. Study of some early immunological parameters in aging humans.

4. Admission criteria for immunogerontological studies in man: the SENIEUR protocol.

5. The immune status of healthy centenarians.

6. Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response.

7. Age-associated increase in interleukin 6 in MRL/lpr mice.

8. Immunoglobulin patterns in humans over 95 years of age.

9. Thyroid and other organ-specific autoantibodies in healthy centenarians.

10. Interleukin-2 production and activity in aged humans.

1. Age-related alterations of somatic hypermutation and CDR3 lengths in human Vkappa4-expressing B lymphocytes.

2. Age-dependent altered proportions in subpopulations of tonsillar lymphocytes.

Review 3. Zinc: dietary intake and impact of supplementation on immune function in elderly.

Review 4. Age effects on B cells and humoral immunity in humans.

Review 5. Global Disparities and Their Implications in the Occurrence and Outcome of Autoimmune Hepatitis.

6. Changes in natural killer cells, the CD57CD8 subset, and related cytokines in healthy aging.

Review 7. Effects of aging on B cell function.

Review 8. Optimization of immunotherapy in elderly cancer patients.

Review 9. Pharmacology and therapeutic effects of dehydroepiandrosterone in older subjects.

10. The immune system and the impact of zinc during aging.