Literature DB >> 25424820

Premature B-cell senescence as a consequence of chronic immune activation.

Paolo Palma1, Stefano Rinaldi, Nicola Cotugno, Veronica Santilli, Savita Pahwa, Paolo Rossi, Alberto Cagigi.   

Abstract

Similar features between the immune system of healthy elderly people and of younger individuals subjected to conditions of chronic immune activation are progressively being observed. This is raising the hypothesis that chronic immune activation may cause the premature aging of the immune system. Here we dissect this theory by comparing changes occurring to B-cells during healthy aging to the ones occurring during chronic immune activation in younger individuals. Moreover, we discuss how these changes may affect or predict response to vaccination in immune compromised individuals.

Entities:  

Keywords:  activation-induced deaminase (AID); aging; double negative B-cells; immunization; immunosenescence; inflammaging; mature-activated B-cells; predictive biomarkers

Mesh：

Year:  2014        PMID： 25424820      PMCID： PMC4186020          DOI： 10.4161/hv.28698

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN： 2164-5515            Impact factor:   3.452


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