Literature DB >> 16464563

AID in somatic hypermutation and class switch recombination.

Simonne Longerich1, Uttiya Basu, Frederick Alt, Ursula Storb.   

Abstract

Somatic hypermutation and class-switch-recombination are initiated by the deamination of deoxycytosine in DNA by activation-induced-deaminase, AID. Recently, there has been much research into how AID targets double-stranded DNA in sub-regions of Ig genes, the involvement of co-factors and posttranslational modifications in this process, the co-option of DNA 'repair' mechanisms and AID evolution.

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Year:  2006        PMID： 16464563     DOI： 10.1016/j.coi.2006.01.008

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  84 in total

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4.  Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region.

Authors:  Feng-Ting Huang; Kefei Yu; Barbara B Balter; Erik Selsing; Zeliha Oruc; Ahmed Amine Khamlichi; Chih-Lin Hsieh; Michael R Lieber
Journal:  Mol Cell Biol       Date:  2007-06-11       Impact factor: 4.272

5.  Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G.

Authors:  Kuan-Ming Chen; Natalia Martemyanova; Yongjian Lu; Keisuke Shindo; Hiroshi Matsuo; Reuben S Harris
Journal:  FEBS Lett       Date:  2007-09-07       Impact factor: 4.124

6.  AID expression increased by TNF-α is associated with class switch recombination of Igα gene in cancers.

Authors:  Zhi Duan; Hui Zheng; Haidan Liu; Ming Li; Min Tang; Xinxian Weng; Wei Yi; Ann M Bode; Ya Cao
Journal:  Cell Mol Immunol       Date:  2015-04-06       Impact factor: 11.530

7.  SHMTool: a webserver for comparative analysis of somatic hypermutation datasets.

Authors:  Thomas Maccarthy; Sergio Roa; Matthew D Scharff; Aviv Bergman
Journal:  DNA Repair (Amst)       Date:  2008-11-08

8.  Deficiency of the oxidative damage-specific DNA glycosylase NEIL1 leads to reduced germinal center B cell expansion.

Authors:  Hiromi Mori; Rika Ouchida; Atsushi Hijikata; Hiroshi Kitamura; Osamu Ohara; Yingqian Li; Xiang Gao; Akira Yasui; R Stephen Lloyd; Ji-Yang Wang
Journal:  DNA Repair (Amst)       Date:  2009-09-24

9.  Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching.

Authors:  Jeroen E J Guikema; Carol E Schrader; Niek G J Leus; Anna Ucher; Erin K Linehan; Uwe Werling; Winfried Edelmann; Janet Stavnezer
Journal:  J Immunol       Date:  2008-12-15       Impact factor: 5.422

10.  The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription.

Authors:  Hong Ming Shen; Michael G Poirier; Michael J Allen; Justin North; Ratnesh Lal; Jonathan Widom; Ursula Storb
Journal:  J Exp Med       Date:  2009-04-20       Impact factor: 14.307
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