CONTEXT: Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown. OBJECTIVE: The aim was to examine the association of change in weight, body mass index (BMI), and waist circumference with change in C-reactive protein (CRP) and IL-6 and to assess whether this association is modified by baseline obesity status. DESIGN AND SETTING: The design was a prospective cohort study among civil servants (the Whitehall II Study, UK). We used data from two clinical screenings carried out in 1991-1993 and 2002-2004 (mean follow-up, 11.3 yr). PARTICIPANTS: We studied 2496 men and 1026 women [mean age, 49.4 (sd=6.0) yr at baseline] with measurements on inflammatory markers and anthropometry at both baseline and follow-up. MAIN OUTCOME MEASURES: We measured change in serum CRP and IL-6 during follow-up. RESULTS: The mean increases in CRP and IL-6 were 0.08 [95% confidence interval (CI), 0.07-0.09] mg/liter and 0.04 (95% CI, 0.03-0.05) pg/ml per 1-kg increase in body weight during follow-up. Study members with a BMI less than 25 kg/m2 at baseline had an average increase in CRP of 0.06 (95% CI, 0.05-0.08) mg/liter per 1-kg increase in body weight, whereas the increase in those who were overweight (25≤BMI<30 kg/m2) and obese (BMI≥30 kg/m2) was greater: 0.08 (95% CI, 0.06-0.09) mg/liter and 0.11 (95% CI, 0.07-0.14) mg/liter, respectively (P value for interaction=0.002). Similar patterns were observed for changes in BMI and waist circumference. CONCLUSIONS: Those who were overweight or obese at baseline had a greater absolute increase in CRP per unit increase in weight, BMI, and waist circumference than people who were normal weight.
CONTEXT: Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown. OBJECTIVE: The aim was to examine the association of change in weight, body mass index (BMI), and waist circumference with change in C-reactive protein (CRP) and IL-6 and to assess whether this association is modified by baseline obesity status. DESIGN AND SETTING: The design was a prospective cohort study among civil servants (the Whitehall II Study, UK). We used data from two clinical screenings carried out in 1991-1993 and 2002-2004 (mean follow-up, 11.3 yr). PARTICIPANTS: We studied 2496 men and 1026 women [mean age, 49.4 (sd=6.0) yr at baseline] with measurements on inflammatory markers and anthropometry at both baseline and follow-up. MAIN OUTCOME MEASURES: We measured change in serum CRP and IL-6 during follow-up. RESULTS: The mean increases in CRP and IL-6 were 0.08 [95% confidence interval (CI), 0.07-0.09] mg/liter and 0.04 (95% CI, 0.03-0.05) pg/ml per 1-kg increase in body weight during follow-up. Study members with a BMI less than 25 kg/m2 at baseline had an average increase in CRP of 0.06 (95% CI, 0.05-0.08) mg/liter per 1-kg increase in body weight, whereas the increase in those who were overweight (25≤BMI<30 kg/m2) and obese (BMI≥30 kg/m2) was greater: 0.08 (95% CI, 0.06-0.09) mg/liter and 0.11 (95% CI, 0.07-0.14) mg/liter, respectively (P value for interaction=0.002). Similar patterns were observed for changes in BMI and waist circumference. CONCLUSIONS: Those who were overweight or obese at baseline had a greater absolute increase in CRP per unit increase in weight, BMI, and waist circumference than people who were normal weight.
Authors: Andrew W Fogarty; Caoimhe Glancy; Stuart Jones; Sarah A Lewis; Tricia M McKeever; John R Britton Journal: Am J Clin Nutr Date: 2008-01 Impact factor: 7.045
Authors: Fred K Tabung; Susan E Steck; Jiajia Zhang; Yunsheng Ma; Angela D Liese; Ilir Agalliu; Melanie Hingle; Lifang Hou; Thomas G Hurley; Li Jiao; Lisa W Martin; Amy E Millen; Hannah L Park; Milagros C Rosal; James M Shikany; Nitin Shivappa; Judith K Ockene; James R Hebert Journal: Ann Epidemiol Date: 2015-03-19 Impact factor: 3.797
Authors: John R Koethe; Cathy A Jenkins; Bryan Lau; Bryan E Shepherd; Amy C Justice; Janet P Tate; Kate Buchacz; Sonia Napravnik; Angel M Mayor; Michael A Horberg; Aaron J Blashill; Amanda Willig; C William Wester; Michael J Silverberg; John Gill; Jennifer E Thorne; Marina Klein; Joseph J Eron; Mari M Kitahata; Timothy R Sterling; Richard D Moore Journal: AIDS Res Hum Retroviruses Date: 2015-09-09 Impact factor: 2.205
Authors: Corinne E Joshu; Kostantinos K Tsilidis; Sarah B Peskoe; Francis M Giardiello; Paul J Dluzniewski; William G Nelson; Christine A Iacobuzio-Donahue; Elizabeth A Platz Journal: Cancer Causes Control Date: 2014-01-17 Impact factor: 2.506
Authors: Ellen L de Hollander; Wanda Je Bemelmans; Hendriek C Boshuizen; Nele Friedrich; Henri Wallaschofski; Pilar Guallar-Castillón; Stefan Walter; M Carola Zillikens; Annika Rosengren; Lauren Lissner; Julie K Bassett; Graham G Giles; Nicola Orsini; Noor Heim; Marjolein Visser; Lisette Cpgm de Groot Journal: Int J Epidemiol Date: 2012-03-31 Impact factor: 7.196
Authors: Mark Hamer; Severine Sabia; G David Batty; Martin J Shipley; Adam G Tabák; Archana Singh-Manoux; Mika Kivimaki Journal: Circulation Date: 2012-08-13 Impact factor: 29.690