BACKGROUND: An increase in weight is a risk factor for cardiovascular disease and cancer. This increased risk may be mediated by inflammation, but no long-term data are available on the effect of weight gain on systemic inflammation. OBJECTIVE: We tested the hypothesis that weight gain is associated with an increase in systemic inflammation during a 9-y period. DESIGN: In 1991 data on body weight and a blood sample were collected from a random sample of 2425 randomly selected adults from a community-based cohort in Nottingham, United Kingdom. In 2000, these measures were repeated in 1301 of these participants. The main outcome measure was change in systemic inflammation as measured by serum C-reactive protein (CRP) from the 1222 participants who provided paired samples. RESULTS: The mean change in weight from 1991 to 2000 was 2.9 kg (95% CI: 2.6, 3.2 kg). The geometric mean of CRP in 1991 was 1.22 mg/L (95% CI: 0.03, 125.0 mg/L), and it increased to 1.76 mg/L (95% CI: 0.09, 62.0 mg/L) in 2000 (P<0.001). A linear association was observed between increase in weight and serum CRP, with a 1-kg increment in weight being associated with an additional increase in CRP of 0.09 mg/L (95% CI: 0.02, 0.16 mg/L) during this time period. CONCLUSION: During a 9-y period, an increase in weight is associated with an increase in systemic inflammation. This provides a mechanism that may explain some of the previously reported association of weight gain with an increased risk of both cancer and cardiovascular disease.
BACKGROUND: An increase in weight is a risk factor for cardiovascular disease and cancer. This increased risk may be mediated by inflammation, but no long-term data are available on the effect of weight gain on systemic inflammation. OBJECTIVE: We tested the hypothesis that weight gain is associated with an increase in systemic inflammation during a 9-y period. DESIGN: In 1991 data on body weight and a blood sample were collected from a random sample of 2425 randomly selected adults from a community-based cohort in Nottingham, United Kingdom. In 2000, these measures were repeated in 1301 of these participants. The main outcome measure was change in systemic inflammation as measured by serum C-reactive protein (CRP) from the 1222 participants who provided paired samples. RESULTS: The mean change in weight from 1991 to 2000 was 2.9 kg (95% CI: 2.6, 3.2 kg). The geometric mean of CRP in 1991 was 1.22 mg/L (95% CI: 0.03, 125.0 mg/L), and it increased to 1.76 mg/L (95% CI: 0.09, 62.0 mg/L) in 2000 (P<0.001). A linear association was observed between increase in weight and serum CRP, with a 1-kg increment in weight being associated with an additional increase in CRP of 0.09 mg/L (95% CI: 0.02, 0.16 mg/L) during this time period. CONCLUSION: During a 9-y period, an increase in weight is associated with an increase in systemic inflammation. This provides a mechanism that may explain some of the previously reported association of weight gain with an increased risk of both cancer and cardiovascular disease.
Authors: R Villegas; Y B Xiang; H Cai; T Elasy; Q Cai; X Zhang; S Fazio; M F Linton; H Li; W H Xu; G Yang; W Zheng; X-O Shu Journal: Nutr Metab Cardiovasc Dis Date: 2010-11-25 Impact factor: 4.222
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Authors: Julienne N Rutherford; Thomas W McDade; Nanette R Lee; Linda S Adair; Christopherw Kuzawa Journal: Am J Hum Biol Date: 2010 May-Jun Impact factor: 1.937
Authors: Micah L Olson; Ana Rentería-Mexía; Margery A Connelly; Sonia Vega-López; Erica G Soltero; Yolanda P Konopken; Allison N Williams; Felipe G Castro; Colleen S Keller; Hongwei P Yang; Michael W Todd; Gabriel Q Shaibi Journal: J Clin Lipidol Date: 2018-09-22 Impact factor: 4.766
Authors: Suzan Wopereis; Carina M Rubingh; Marjan J van Erk; Elwin R Verheij; Trinette van Vliet; Nicole H P Cnubben; Age K Smilde; Jan van der Greef; Ben van Ommen; Henk F J Hendriks Journal: PLoS One Date: 2009-02-26 Impact factor: 3.240