Literature DB >> 23597402

Enantioselective thiourea-catalyzed intramolecular cope-type hydroamination.

Adam R Brown1, Christopher Uyeda, Carolyn A Brotherton, Eric N Jacobsen.   

Abstract

Catalysis of Cope-type rearrangements of bis-homoallylic hydroxylamines is demonstrated using chiral thiourea derivatives. This formal intramolecular hydroamination reaction provides access to highly enantioenriched α-substituted pyrrolidine products and represents a complementary approach to metal-catalyzed methods.

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Year:  2013        PMID： 23597402      PMCID： PMC3689223          DOI： 10.1021/ja402893z

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  51 in total

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10.  Nucleophile-Assisted Alkene Activation: Olefins Alone Are Often Incompetent.

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