Nilesh V Patel 1 , Amr M Ghaleb , Mandayam O Nandan , Vincent W Yang Show Affiliations »
Abstract
BACKGROUND: The zinc finger transcription factor Krüppel-like factor 4 (KLF4) regulates numerous physiologic processes, including proliferation, differentiation, and development. Studies also showed that KLF4 is involved in tumorigenesis and somatic cell reprogramming. Here, we aimed to assess whether KLF4 is a prognostic indicator for colon cancer. METHODS: Levels of KLF4 were measured by immunohistochemical analysis of a tissue microarray containing 367 independent colon cancer sections. Univariate data analysis was done in addition to construction of multivariate models with several clinicopathologic factors to evaluate KLF4 as an independent predictor of survival and cancer recurrence (disease-free survival). RESULTS: Colon cancer tissues had significantly overall lower KLF4 levels compared with noncancer tissues (P < 0.0001). Using logistic regression, a trend was noted for decreased odds of KLF4 expression in higher stages of tumors. In univariate and multivariate analyses, KLF4 was a significant predictor of survival and recurrence. CONCLUSIONS: KLF4 expression is significantly downregulated in colon cancer, and loss of KLF4 is an independent predictor of survival and recurrence. IMPACT: These findings suggest that KLF4 may serve as a prognostic biomarker for colon cancer. ©2010 AACR.
BACKGROUND: The zinc finger transcription factor Krüppel-like factor 4 (KLF4 ) regulates numerous physiologic processes, including proliferation, differentiation, and development. Studies also showed that KLF4 is involved in tumorigenesis and somatic cell reprogramming. Here, we aimed to assess whether KLF4 is a prognostic indicator for colon cancer . METHODS: Levels of KLF4 were measured by immunohistochemical analysis of a tissue microarray containing 367 independent colon cancer sections. Univariate data analysis was done in addition to construction of multivariate models with several clinicopathologic factors to evaluate KLF4 as an independent predictor of survival and cancer recurrence (disease-free survival). RESULTS: Colon cancer tissues had significantly overall lower KLF4 levels compared with noncancer tissues (P < 0.0001). Using logistic regression, a trend was noted for decreased odds of KLF4 expression in higher stages of tumors . In univariate and multivariate analyses, KLF4 was a significant predictor of survival and recurrence. CONCLUSIONS: KLF4 expression is significantly downregulated in colon cancer , and loss of KLF4 is an independent predictor of survival and recurrence. IMPACT: These findings suggest that KLF4 may serve as a prognostic biomarker for colon cancer . ©2010 AACR.
Entities: Chemical
Disease
Gene
Species
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Year: 2010
PMID： 20699379 PMCID： PMC2952064 DOI： 10.1158/1055-9965.EPI-10-0677
Source DB: PubMed Journal: Cancer Epidemiol Biomarkers Prev ISSN： 1055-9965 Impact factor: 4.254