Literature DB >> 24105022

Decreased Kruppel-like factor 4 (KLF4) expression may correlate with poor survival in gastric adenocarcinoma.

Li-Sung Hsu1, Chien-Pin Chan, Chih-Jung Chen, Shu-Hui Lin, Ming-Tsung Lai, Jeng-Dong Hsu, Kun-Tu Yeh, Maw-Soan Soon.   

Abstract

Kruppel-like factors (KLFs) play either anti- or pro-proliferation roles in different human cancers. Here, we investigated the expression of KLF4 in gastric cancers and its correlation with clinicopathological parameters and overall survival. KLF4 expression was measured in 118 surgical specimens by immunohistochemical microarray assay. No association of cytoplasmic KLF4 expression with gender, TNM status, stage, survival, and pathological type was found. Using Kaplan-Meier analysis, significantly higher overall survival rate was observed in patients with high cytoplasmic KLF4 expression compared to low cytoplasmic KLF4 expression. Univariate analysis revealed that cytoplasmic KLF4 expression, grade, histological type, lymph node metastasis, and stages were correlated to longer overall survival. Our results suggest that KLF4 may play an anti-oncogenic role in gastric tumorigenesis.

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Year:  2013        PMID： 24105022     DOI： 10.1007/s12032-013-0632-6

Source DB:  PubMed          Journal:  Med Oncol        ISSN： 1357-0560            Impact factor:   3.064


  32 in total

1.  Loss of nuclear expression of Krüppel-like factor 4 is associated with poor prognosis in patients with oral cancer.

Authors:  Chih-Jung Chen; Li-Sung Hsu; Shu-Hui Lin; Mu-Kuan Chen; Hsin-Kai Wang; Jeng-Dong Hsu; Huei Lee; Kun-Tu Yeh
Journal:  Hum Pathol       Date:  2011-12-29       Impact factor: 3.466

2.  Gut-enriched Krüppel-like factor represses cyclin D1 promoter activity through Sp1 motif.

Authors:  J L Shie; Z Y Chen; M Fu; R G Pestell; C C Tseng
Journal:  Nucleic Acids Res       Date:  2000-08-01       Impact factor: 16.971

Review 3.  Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors.

Authors:  J Turner; M Crossley
Journal:  Int J Biochem Cell Biol       Date:  1999-10       Impact factor: 5.085

4.  Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle.

Authors:  X Chen; D C Johns; D E Geiman; E Marban; D T Dang; G Hamlin; R Sun; V W Yang
Journal:  J Biol Chem       Date:  2001-06-04       Impact factor: 5.157

5.  Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach.

Authors:  Jonathan P Katz; Nathalie Perreault; Bree G Goldstein; Lori Actman; Sara R McNally; Debra G Silberg; Emma E Furth; Klaus H Kaestner
Journal:  Gastroenterology       Date:  2005-04       Impact factor: 22.682

6.  Persistent Krüppel-like factor 4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma.

Authors:  Shyh-Kuan Tai; Muh-Hwa Yang; Shyue-Yih Chang; Yung-Chi Chang; Wing-Yin Li; Tung-Lung Tsai; Yi-Fen Wang; Pen-Yuan Chu; Shie-Liang Hsieh
Journal:  Cancer Sci       Date:  2011-03-04       Impact factor: 6.716

7.  Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation.

Authors:  J L Shie; Z Y Chen; M J O'Brien; R G Pestell; M E Lee; C C Tseng
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2000-10       Impact factor: 4.052

8.  Loss of Krüppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progression.

Authors:  Masashi Kanai; Daoyan Wei; Qiang Li; Zhiliang Jia; Jaffer Ajani; Xiangdong Le; James Yao; Keping Xie
Journal:  Clin Cancer Res       Date:  2006-11-01       Impact factor: 12.531

Review 9.  Chromosomal deletions and tumor suppressor genes in prostate cancer.

Authors:  J T Dong
Journal:  Cancer Metastasis Rev       Date:  2001       Impact factor: 9.264

10.  Nuclear Krüppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis.

Authors:  Yi-Ju Chen; Chun-Ying Wu; Chia-Che Chang; Chieh-Ju Ma; Mu-Chun Li; Chuan-Mu Chen
Journal:  Cancer Biol Ther       Date:  2008-05-20       Impact factor: 4.742
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  11 in total

Review 1.  SP and KLF Transcription Factors in Digestive Physiology and Diseases.

Authors:  Chang-Kyung Kim; Ping He; Agnieszka B Bialkowska; Vincent W Yang
Journal:  Gastroenterology       Date:  2017-03-30       Impact factor: 22.682

2.  Negative Regulation of Kruppel-Like Factor 4 on microRNA-106a at Upstream Transcriptional Level and the Role in Gastric Cancer Metastasis.

Authors:  Meng Zhu; Ning Zhang; Xinlan Lu; Shuixiang He
Journal:  Dig Dis Sci       Date:  2018-06-08       Impact factor: 3.199

3.  Expression levels of SOX2, KLF4 and brachyury transcription factors are associated with metastasis and poor prognosis in oral squamous cell carcinoma.

Authors:  Rumi Yoshihama; Koujiro Yamaguchi; Ikumi Imajyo; Mariko Mine; Naomi Hiyake; Naonari Akimoto; Yosuke Kobayashi; Satomi Chigita; Wataru Kumamaru; Tamotsu Kiyoshima; Yoshihide Mori; Tsuyoshi Sugiura
Journal:  Oncol Lett       Date:  2015-12-22       Impact factor: 2.967

4.  Augmented miR-10b expression associated with depressed expression of its target gene KLF4 involved in gastric carcinoma.

Authors:  Zhihong Ma; Yingrong Chen; Lishan Min; Liqin Li; Huilian Huang; Jing Li; Qiang Yan; Pengtao Song; Lichen Dai; Xing Yao
Journal:  Int J Clin Exp Pathol       Date:  2015-05-01

5.  Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance.

Authors:  Zhuan Zhou; Xinxin Song; Junlong Jack Chi; David R Gius; Yi Huang; Massimo Cristofanilli; Yong Wan
Journal:  Cell Signal       Date:  2020-02-19       Impact factor: 4.315

Review 6.  Murine Models of Gastric Corpus Preneoplasia.

Authors:  Christine P Petersen; Jason C Mills; James R Goldenring
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2016-11-16

Review 7.  The Prognostic Value of Decreased KLF4 in Digestive System Cancers: A Meta-Analysis from 17 Studies.

Authors:  Jianpei Hu; Huipu Li; Chunyu Wu; Xueying Zhao; Chaodong Liu
Journal:  Dis Markers       Date:  2017-09-14       Impact factor: 3.434

8.  Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway.

Authors:  Qing Xu; Mei Liu; Ju Zhang; Liyan Xue; Guo Zhang; Chenfei Hu; Zaozao Wang; Shun He; Lechuang Chen; Kai Ma; Xianghe Liu; Yahui Zhao; Ning Lv; Shufang Liang; Hongxia Zhu; Ningzhi Xu
Journal:  Oncotarget       Date:  2016-09-13

9.  Role of Kruppel-like factor 4 in regulating inhibitor of apoptosis-stimulating protein of p53 in the progression of gastric cancer.

Authors:  Lulu Wang; Yan Li; Luchun Li; Zhijuan Wu; Yongzhong Wu; Huiwen Ma; Huiqing Yu; Dan Yang; Donglin Wang
Journal:  Oncol Lett       Date:  2018-03-07       Impact factor: 2.967

10.  LncRNA SNHG3 enhances the malignant progress of glioma through silencing KLF2 and p21.

Authors:  Fan Fei; Yongsheng He; Sen He; Zhongze He; Youyu Wang; Gang Wu; Mengni Li
Journal:  Biosci Rep       Date:  2018-09-07       Impact factor: 3.840
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