Literature DB >> 28237823

Krüppel-like factor 4 (KLF4): What we currently know.

Amr M Ghaleb1, Vincent W Yang2.   

Abstract

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4 has been gaining a lot of attention, particularly after it was shown in 2006 as one of four factors involved in the induction of pluripotent stem cells (iPSCs). Here we review the current knowledge about the different functions and roles of KLF4 in various tissue and organ systems.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cancer; Cell cycle; Differentiation; Diseases; Epithelial-to-mesenchymal transition; Gene expression; Inflammation; KLF4; Organs; Proliferation; Stem cells; Tissues; Transcription

Mesh：

Substances：

Year:  2017        PMID： 28237823      PMCID： PMC5391259          DOI： 10.1016/j.gene.2017.02.025

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  178 in total

1.  p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells.

Authors:  Andreia V Pinho; Ilse Rooman; Francisco X Real
Journal:  Cell Cycle       Date:  2011-04-15       Impact factor: 4.534

Review 2.  Krüppel-like transcription factors and control of pluripotency.

Authors:  Pierre-Yves Bourillot; Pierre Savatier
Journal:  BMC Biol       Date:  2010-09-27       Impact factor: 7.431

3.  A global role for zebrafish klf4 in embryonic erythropoiesis.

Authors:  M R Gardiner; M M Gongora; S M Grimmond; A C Perkins
Journal:  Mech Dev       Date:  2007-06-23       Impact factor: 1.882

4.  Krüppel-like factor 4 inhibits the expression of interleukin-1 beta in lipopolysaccharide-induced RAW264.7 macrophages.

Authors:  Junwen Liu; Tao Yang; Ying Liu; Huali Zhang; Kangkai Wang; Meidong Liu; Guangwen Chen; Xianzhong Xiao
Journal:  FEBS Lett       Date:  2012-02-13       Impact factor: 4.124

5.  Shaking the family tree: identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.

Authors:  Olga Camacho-Vanegas; Jacob Till; Irene Miranda-Lorenzo; Berrin Ozturk; Sandra Catalina Camacho; John A Martignetti
Journal:  FASEB J       Date:  2012-11-07       Impact factor: 5.191

Review 6.  Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression.

Authors:  Thomas Brabletz; Andreas Jung; Simone Spaderna; Falk Hlubek; Thomas Kirchner
Journal:  Nat Rev Cancer       Date:  2005-09       Impact factor: 60.716

Review 7.  Initial events in the cellular effects of ionizing radiations: clustered damage in DNA.

Authors:  D T Goodhead
Journal:  Int J Radiat Biol       Date:  1994-01       Impact factor: 2.694

8.  HIV vasculopathy: role of mononuclear cell-associated Krüppel-like factors 2 and 4.

Authors:  Andrew T Hale; Chris T Longenecker; Ying Jiang; Sara M Debanne; Danielle E Labatto; Norma Storer; Anne Hamik; Grace A McComsey
Journal:  AIDS       Date:  2015-08-24       Impact factor: 4.177

9.  Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest.

Authors:  J M Shields; R J Christy; V W Yang
Journal:  J Biol Chem       Date:  1996-08-16       Impact factor: 5.157

10.  KLF4 is a FOXO target gene that suppresses B cell proliferation.

Authors:  Isharat Yusuf; Michael G Kharas; Jing Chen; Raechel Q Peralta; Autumn Maruniak; Pratibha Sareen; Vincent W Yang; Klaus H Kaestner; David A Fruman
Journal:  Int Immunol       Date:  2008-03-28       Impact factor: 4.823
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  135 in total

1.  Role of Krüppel-like factor 4 and heat shock protein 27 in cancer of the larynx.

Authors:  Jihad Karam; Marie Claude Fadous-Khalifé; Rita Tannous; Sally Fakhreddine; Marcel Massoud; Joseph Hadchity; Georges Aftimos; Elie Hadchity
Journal:  Mol Clin Oncol       Date:  2017-09-19

Review 2.  Emerging role of FBXO22 in carcinogenesis.

Authors:  Jiangting Cheng; Min Lin; Man Chu; Longyuan Gong; Yanli Bi; Yongchao Zhao
Journal:  Cell Death Discov       Date:  2020-07-27

3.  TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression.

Authors:  Zhen Ni; Yali Min; Chuan Han; Ting Yuan; Wenquan Lu; Hassan Ashktorab; Duane T Smoot; Qiong Wu; Jian Wu; Weizheng Zeng; Yongquan Shi
Journal:  Cell Death Discov       Date:  2020-07-06

4.  Two Pioneer Transcription Factors, Krüppel-Like Transcription Factor 4 and Glucocorticoid Receptor, Cooperatively Transactivate the Bovine Herpesvirus 1 ICP0 Early Promoter and Stimulate Productive Infection.

Authors:  Fouad S El-Mayet; Laximan Sawant; Prasanth Thunuguntla; Jing Zhao; Clinton Jones
Journal:  J Virol       Date:  2020-01-31       Impact factor: 5.103

5.  Role of Krüppel-like factor 4 in cigarette smoke-induced pulmonary vascular remodeling.

Authors:  Desheng Sun; Qinghai Li; Dandan Ding; Xiaochen Li; Min Xie; Yongjian Xu; Xiansheng Liu
Journal:  Am J Transl Res       Date:  2018-02-15       Impact factor: 4.060

6.  Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming.

Authors:  Keshi Chen; Qi Long; Guangsuo Xing; Tianyu Wang; Yi Wu; Linpeng Li; Juntao Qi; Yanshuang Zhou; Bochao Ma; Hans R Schöler; Jinfu Nie; Duanqing Pei; Xingguo Liu
Journal:  EMBO J       Date:  2019-10-01       Impact factor: 11.598

7.  Microarray-based Analysis of Genes, Transcription Factors, and Epigenetic Modifications in Lung Cancer Exposed to Nitric Oxide.

Authors:  Arnatchai Maiuthed; Ornjira Prakhongcheep; Pithi Chanvorachote
Journal:  Cancer Genomics Proteomics       Date:  2020 Jul-Aug       Impact factor: 4.069

8.  Transactivation of Herpes Simplex Virus 1 (HSV-1) Infected Cell Protein 4 Enhancer by Glucocorticoid Receptor and Stress-Induced Transcription Factors Requires Overlapping Krüppel-Like Transcription Factor 4/Sp1 Binding Sites.

Authors:  Jeffery B Ostler; Prasanth Thunuguntla; Bailey Y Hendrickson; Clinton Jones
Journal:  J Virol       Date:  2021-01-28       Impact factor: 5.103

Review 9.  MicroRNAs Involved in Metastasis of Hepatocellular Carcinoma: Target Candidates, Functionality and Efficacy in Animal Models and Prognostic Relevance.

Authors:  Ulrich H Weidle; Daniela Schmid; Fabian Birzele; Ulrich Brinkmann
Journal:  Cancer Genomics Proteomics       Date:  2020 Jan-Feb       Impact factor: 4.069

10.  Inflammation-induced colon cancer in uPA-deficient mice is associated with a deregulated expression of Notch signaling pathway components.

Authors:  Hara Afaloniati; George S Karagiannis; Emmanouel Karavanis; Theophano A Psarra; Anastasios Karampatzakis-Kouritas; Theofilos Poutahidis; Katerina Angelopoulou
Journal:  Mol Cell Biochem       Date:  2019-11-22       Impact factor: 3.396
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