Literature DB >> 20697928

Molecular cloning and characterization of the global regulator LaeA in Penicillium citrinum.

Wei Xing1, Chao Deng, Chang-Hua Hu.   

Abstract

We have cloned and analysed a laeA gene (Pci-laeA) that may control mevastatin biosynthesis in Penicillium citrinum. The full-length Pci-laeA sequence is 1,340 bp with an ORF of 1,284 bp encoding 427 amino acids. It shows 95% identity with LaeA from P. chrysogenum. The predicted molecular mass of Pci-LaeA is 48.72 kDa with an estimated theoretical isoelectric point of 6.96. Pci-LaeA has a conserved S-adenosylmethionine binding site and a potential MlcR (a pathway specific regulator in mevastatin biosynthesis) binding site.

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Year:  2010        PMID： 20697928     DOI： 10.1007/s10529-010-0375-9

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  6 in total

Review 1.  Transcriptional regulatory elements in fungal secondary metabolism.

Authors:  Wenbing Yin; Nancy P Keller
Journal:  J Microbiol       Date:  2011-06-30       Impact factor: 3.422

Review 2.  Advances in Aspergillus secondary metabolite research in the post-genomic era.

Authors:  James F Sanchez; Amber D Somoza; Nancy P Keller; Clay C C Wang
Journal:  Nat Prod Rep       Date:  2012-01-06       Impact factor: 13.423

3.  Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi.

Authors:  Fang Yun Lim; James F Sanchez; Clay C C Wang; Nancy P Keller
Journal:  Methods Enzymol       Date:  2012       Impact factor: 1.600

Review 4.  The chromatin code of fungal secondary metabolite gene clusters.

Authors:  Agnieszka Gacek; Joseph Strauss
Journal:  Appl Microbiol Biotechnol       Date:  2012-07-20       Impact factor: 4.813

5.  The bZIP protein MeaB mediates virulence attributes in Aspergillus flavus.

Authors:  Saori Amaike; Katharyn J Affeldt; Wen-Bing Yin; Stephen Franke; Anjali Choithani; Nancy P Keller
Journal:  PLoS One       Date:  2013-09-09       Impact factor: 3.240

6.  Identification of a Classical Mutant in the Industrial Host Aspergillus niger by Systems Genetics: LaeA Is Required for Citric Acid Production and Regulates the Formation of Some Secondary Metabolites.

Authors:  Jing Niu; Mark Arentshorst; P Deepa S Nair; Ziyu Dai; Scott E Baker; Jens C Frisvad; Kristian F Nielsen; Peter J Punt; Arthur F J Ram
Journal:  G3 (Bethesda)       Date:  2015-11-13       Impact factor: 3.154
  6 in total

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