Pim Pullens1, Alard Roebroeck, Rainer Goebel. 1. Maastricht Brain Imaging Center, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands. pim.pullens@maastrichtuniversity.nl
Abstract
PURPOSE: To quantitatively validate diffusion-weighted MRI (DW-MRI) applications, a hardware phantom containing crossing fibers at a sub-voxel level is presented. It is suitable for validation of a large spectrum of DW-MRI applications from acquisition to fiber tracking, which is an important recurrent issue in the field. MATERIALS AND METHODS: Phantom properties were optimized to resemble properties of human white matter in terms of anisotropy, fractional anisotropy, and T(2). Sub-voxel crossings were constructed at angles of 30, 50, and 65 degrees, by wrapping polyester fibers, with a diameter close to axon diameter, into heat shrink tubes. We show our phantoms are suitable for the acquisition of DW-MRI data using a clinical protocol. RESULTS: The phantoms can be used to successfully estimate both the diffusion tensor and non-Gaussian diffusion models, and perform streamline fiber tracking. DOT (Diffusion Orientation Transform) and q-ball reconstruction of the diffusion profiles acquired at b = 3000 s/mm(2) and 132 diffusion directions reveal multimodal diffusion profiles in voxels containing crossing yarn strands. CONCLUSION: The highly purpose adaptable phantoms provide a DW-MRI validation platform: applications include optimisation of acquisition schemes, validation of non-Gaussian diffusion models, comparison and validation of fiber tracking algorithms, and quality control in multi-center DWI studies. 2010 Wiley-Liss, Inc.
PURPOSE: To quantitatively validate diffusion-weighted MRI (DW-MRI) applications, a hardware phantom containing crossing fibers at a sub-voxel level is presented. It is suitable for validation of a large spectrum of DW-MRI applications from acquisition to fiber tracking, which is an important recurrent issue in the field. MATERIALS AND METHODS: Phantom properties were optimized to resemble properties of human white matter in terms of anisotropy, fractional anisotropy, and T(2). Sub-voxel crossings were constructed at angles of 30, 50, and 65 degrees, by wrapping polyester fibers, with a diameter close to axon diameter, into heat shrink tubes. We show our phantoms are suitable for the acquisition of DW-MRI data using a clinical protocol. RESULTS: The phantoms can be used to successfully estimate both the diffusion tensor and non-Gaussian diffusion models, and perform streamline fiber tracking. DOT (Diffusion Orientation Transform) and q-ball reconstruction of the diffusion profiles acquired at b = 3000 s/mm(2) and 132 diffusion directions reveal multimodal diffusion profiles in voxels containing crossing yarn strands. CONCLUSION: The highly purpose adaptable phantoms provide a DW-MRI validation platform: applications include optimisation of acquisition schemes, validation of non-Gaussian diffusion models, comparison and validation of fiber tracking algorithms, and quality control in multi-center DWI studies. 2010 Wiley-Liss, Inc.
Authors: Dogu Baran Aydogan; Russell Jacobs; Stephanie Dulawa; Summer L Thompson; Maite Christi Francois; Arthur W Toga; Hongwei Dong; James A Knowles; Yonggang Shi Journal: Brain Struct Funct Date: 2018-04-16 Impact factor: 3.270
Authors: Qiuyun Fan; Aapo Nummenmaa; Barbara Wichtmann; Thomas Witzel; Choukri Mekkaoui; Walter Schneider; Lawrence L Wald; Susie Y Huang Journal: Neuroimage Date: 2018-01-12 Impact factor: 6.556