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Literature DB >> 20677236

Rotating frame spin lattice relaxation in a swine model of chronic, left ventricular myocardial infarction.

Walter R T Witschey¹, James J Pilla, Giovanni Ferrari, Kevin Koomalsingh, Mohammed Haris, Robin Hinmon, Gerald Zsido, Joseph H Gorman, Robert C Gorman, Ravinder Reddy.

Abstract

T1ρ relaxation times were quantified in a swine model of chronic, left ventricular myocardial infarction. It was found that there were low frequency relaxation mechanisms that suppress endogenous contrast at low spin-lock amplitudes and in T2-weighted images. A moderate amplitude spin-locking pulse could overcome these relaxation mechanisms. Relaxation dispersion data were measured over a range of RF field amplitudes, and a model was formulated to include dipole-dipole relaxation modulated by molecular rotation and an apparent exchange mechanism. These techniques may find some use in the clinic for the observation of chronic, left ventricular cardiac remodeling.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Spin Labels

Year: 2010 PMID： 20677236 PMCID： PMC2965811 DOI： 10.1002/mrm.22543

Source DB: PubMed Journal: Magn Reson Med ISSN： 0740-3194 Impact factor: 4.668

26 in total

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Authors: M I Kettunen; O H Gröhn; M Penttonen; R A Kauppinen
Journal: Magn Reson Med Date: 2001-09 Impact factor: 4.668

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8. Ventricular restraint prevents infarct expansion and improves borderzone function after myocardial infarction: a study using magnetic resonance imaging, three-dimensional surface modeling, and myocardial tagging.

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9. T1rho-prepared balanced gradient echo for rapid 3D T1rho MRI.

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10. Direct measurements of the dissociation-rate constant for inhibitor-enzyme complexes via the T1 rho and T2 (CPMG) methods.

Authors: D G Davis; M E Perlman; R E London
Journal: J Magn Reson B Date: 1994-07

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3. Saddle-Shaped Annuloplasty Improves Leaflet Coaptation in Repair for Ischemic Mitral Regurgitation.

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4. A non-contrast CMR index for assessing myocardial fibrosis.

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5. Myocardium Assessment by Relaxation along Fictitious Field, Extracellular Volume, Feature Tracking, and Myocardial Strain in Hypertensive Patients with Left Ventricular Hypertrophy.

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6. MRI evaluation of injectable hyaluronic acid-based hydrogel therapy to limit ventricular remodeling after myocardial infarction.

Authors: Shauna M Dorsey; Jeremy R McGarvey; Hua Wang; Amir Nikou; Leron Arama; Kevin J Koomalsingh; Norihiro Kondo; Joseph H Gorman; James J Pilla; Robert C Gorman; Jonathan F Wenk; Jason A Burdick
Journal: Biomaterials Date: 2015-08-06 Impact factor: 12.479

7. In vivo chronic myocardial infarction characterization by spin locked cardiovascular magnetic resonance.

Authors: Walter R T Witschey; Gerald A Zsido; Kevin Koomalsingh; Norihiro Kondo; Masahito Minakawa; Takashi Shuto; Jeremy R McGarvey; Melissa M Levack; Francisco Contijoch; James J Pilla; Joseph H Gorman; Robert C Gorman
Journal: J Cardiovasc Magn Reson Date: 2012-06-15 Impact factor: 5.364