Literature DB >> 20659013

The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing.

Rebecca Hogg1, Joanne C McGrail, Raymond T O'Keefe.   

Abstract

The NineTeen Complex (NTC) of proteins associates with the spliceosome during pre-mRNA splicing and is essential for both steps of intron removal. The NTC and other NTC-associated proteins are recruited to the spliceosome where they participate in regulating the formation and progression of essential spliceosome conformations required for the two steps of splicing. It is now clear that the NTC is an integral component of active spliceosomes from yeast to humans and provides essential support for the spliceosomal snRNPs (small nuclear ribonucleoproteins). In the present article, we discuss the identification and characterization of the yeast NTC and review recent work in yeast that supports the essential role for this complex in the regulation and fidelity of splicing.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20659013      PMCID： PMC4234902          DOI： 10.1042/BST0381110

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  50 in total

1.  Prp43: An RNA helicase-like factor involved in spliceosome disassembly.

Authors:  J E Arenas; J N Abelson
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-28       Impact factor: 11.205

2.  Splicing fidelity revisited.

Authors:  Charles C Query; Maria M Konarska
Journal:  Nat Struct Mol Biol       Date:  2006-06       Impact factor: 15.369

3.  Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components.

Authors:  Zbigniew Warkocki; Peter Odenwälder; Jana Schmitzová; Florian Platzmann; Holger Stark; Henning Urlaub; Ralf Ficner; Patrizia Fabrizio; Reinhard Lührmann
Journal:  Nat Struct Mol Biol       Date:  2009-11-22       Impact factor: 15.369

4.  The yeast PRP19 protein is not tightly associated with small nuclear RNAs, but appears to associate with the spliceosome after binding of U2 to the pre-mRNA and prior to formation of the functional spliceosome.

Authors:  W Y Tarn; K R Lee; S C Cheng
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

5.  Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.

Authors:  Evgeny M Makarov; Olga V Makarova; Henning Urlaub; Marc Gentzel; Cindy L Will; Matthias Wilm; Reinhard Lührmann
Journal:  Science       Date:  2002-10-31       Impact factor: 47.728

6.  SNEV overexpression extends the life span of human endothelial cells.

Authors:  Regina Voglauer; Martina Wei-Fen Chang; Brigitta Dampier; Matthias Wieser; Kristin Baumann; Thomas Sterovsky; Martin Schreiber; Hermann Katinger; Johannes Grillari
Journal:  Exp Cell Res       Date:  2006-01-04       Impact factor: 3.905

7.  Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome.

Authors:  Richard J Grainger; J David Barrass; Alain Jacquier; Jean-Christophe Rain; Jean D Beggs
Journal:  RNA       Date:  2009-10-23       Impact factor: 4.942

8.  Cwc23, an essential J protein critical for pre-mRNA splicing with a dispensable J domain.

Authors:  Chandan Sahi; Thomas Lee; Maki Inada; Jeffrey A Pleiss; Elizabeth A Craig
Journal:  Mol Cell Biol       Date:  2010-01       Impact factor: 4.272

9.  Spp382p interacts with multiple yeast splicing factors, including possible regulators of Prp43 DExD/H-Box protein function.

Authors:  Shatakshi Pandit; Sudakshina Paul; Li Zhang; Min Chen; Nicole Durbin; Susan M W Harrison; Brian C Rymond
Journal:  Genetics       Date:  2009-07-06       Impact factor: 4.562

10.  Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1.

Authors:  Silvestro G Conticello; Karuna Ganesh; Kanmin Xue; Mason Lu; Cristina Rada; Michael S Neuberger
Journal:  Mol Cell       Date:  2008-08-22       Impact factor: 17.970
View more
  52 in total

1.  The RNA polymerase C-terminal domain: a new role in spliceosome assembly.

Authors:  Charles J David; James L Manley
Journal:  Transcription       Date:  2011 Sep-Oct

2.  Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS.

Authors:  Thomas Ohrt; Mira Prior; Julia Dannenberg; Peter Odenwälder; Olexandr Dybkov; Nicolas Rasche; Jana Schmitzová; Ingo Gregor; Patrizia Fabrizio; Jörg Enderlein; Reinhard Lührmann
Journal:  RNA       Date:  2012-04-25       Impact factor: 4.942

3.  Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein.

Authors:  Jana Schmitzová; Nicolas Rasche; Olexander Dybkov; Katharina Kramer; Patrizia Fabrizio; Henning Urlaub; Reinhard Lührmann; Vladimir Pena
Journal:  EMBO J       Date:  2012-03-09       Impact factor: 11.598

Review 4.  Alternative splicing at the intersection of biological timing, development, and stress responses.

Authors:  Dorothee Staiger; John W S Brown
Journal:  Plant Cell       Date:  2013-10-31       Impact factor: 11.277

5.  The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex.

Authors:  Charles J David; Alex R Boyne; Scott R Millhouse; James L Manley
Journal:  Genes Dev       Date:  2011-05-01       Impact factor: 11.361

6.  The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes.

Authors:  Inessa De; Sergey Bessonov; Romina Hofele; Karine dos Santos; Cindy L Will; Henning Urlaub; Reinhard Lührmann; Vladimir Pena
Journal:  Nat Struct Mol Biol       Date:  2015-01-19       Impact factor: 15.369

7.  Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA.

Authors:  Hye In Ka; Sunyi Lee; Sora Han; Ae Lee Jeong; Ji Young Park; Hyun Jeong Joo; Su Jung Soh; Doyeon Park; Young Yang
Journal:  Cell Death Discov       Date:  2020-05-04

8.  Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5' splice site and branch site.

Authors:  Daniel J Crawford; Aaron A Hoskins; Larry J Friedman; Jeff Gelles; Melissa J Moore
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-08       Impact factor: 11.205

9.  Saccharomyces cerevisiae NineTeen complex (NTC)-associated factor Bud31/Ycr063w assembles on precatalytic spliceosomes and improves first and second step pre-mRNA splicing efficiency.

Authors:  Debjani Saha; Piyush Khandelia; Raymond T O'Keefe; Usha Vijayraghavan
Journal:  J Biol Chem       Date:  2012-01-03       Impact factor: 5.157

10.  Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre.

Authors:  Nicolas Rasche; Olexandr Dybkov; Jana Schmitzová; Berktan Akyildiz; Patrizia Fabrizio; Reinhard Lührmann
Journal:  EMBO J       Date:  2012-01-13       Impact factor: 11.598
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.