Literature DB >> 20655266

Rac GTPases in erythroid biology.

D G Konstantinidis1, A George, T A Kalfa.   

Abstract

Rac1 and Rac2 GTPases, members of the Rho GTPases family, control actin organization and play distinct and overlapping roles in hematopoietic and mature blood cells of all lineages. Here, we review our findings on the role of Rac GTPases in erythroid cells, by using conditional gene-targeting in mice. Rac1 and Rac2 deficiency causes anemia with reticulocytosis, indicating decreased red blood cell (RBC) survival, altered actin assembly in the erythrocyte membrane skeleton and decreased RBC deformability. On the other hand, Rac1(-/-); Rac2(-/-) megakaryocyte-erythrocyte progenitors demonstrate decreased proliferation in the bone marrow, but increased survival and proliferation in the spleen, indicating that stress erythropoiesis circumvents Rac GTPases deficiency. Further elucidation of the signaling pathways controlled by Rac GTPases in erythroid cells may reveal potential therapeutic targets for diseases characterized by hemolytic anemia and erythropoiesis disorders. Copyright 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20655266      PMCID： PMC4473774          DOI： 10.1016/j.tracli.2010.05.002

Source DB:  PubMed          Journal:  Transfus Clin Biol        ISSN： 1246-7820            Impact factor:   1.406


  38 in total

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Journal:  Oncogene       Date:  1998-12-31       Impact factor: 9.867

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Authors:  Martin Schwartz
Journal:  J Cell Sci       Date:  2004-11-01       Impact factor: 5.285

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Authors:  N V Shirsat; R J Pignolo; B L Kreider; G Rovera
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Review 8.  Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species.

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Authors:  J Moll; G Sansig; E Fattori; H van der Putten
Journal:  Oncogene       Date:  1991-05       Impact factor: 9.867

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Authors:  Theodosia A Kalfa; Suvarnamala Pushkaran; Xiaoling Zhang; James F Johnson; Dao Pan; Deidre Daria; Hartmut Geiger; Jose A Cancelas; David A Williams; Yi Zheng
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  4 in total

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