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Literature DB >> 10030666

Rac1 is required for the formation of three germ layers during gastrulation.

K Sugihara¹, N Nakatsuji, K Nakamura, K Nakao, R Hashimoto, H Otani, H Sakagami, H Kondo, S Nozawa, A Aiba, M Katsuki.

Abstract

The Rac1, a member of the Rho family proteins, regulates actin organization of cytoskeleton and cell adhesion. We used genetic analysis to elucidate the role of Rac1 in mouse embryonic development. The rac1 deficient embryos showed numerous cell deaths in the space between the embryonic ectoderm and endoderm at the primitive streak stage. Investigation of the primary epiblast culture isolated from rac1 deficient embryos indicated that Rac1 is involved in lamellipodia formation, cell adhesion and cell migration in vivo. These results suggest that Rac1-mediated cell adhesion is essential for the formation of three germ layers during gastrulation.

Entities: Gene Species

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Year: 1998 PMID： 10030666 DOI： 10.1038/sj.onc.1202595

Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867

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Cited

134 in total

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2. PAK4 kinase is essential for embryonic viability and for proper neuronal development.

Authors: Jian Qu; Xiaofan Li; Bennet G Novitch; Ye Zheng; Matthew Kohn; Jian-Ming Xie; Spencer Kozinn; Roderick Bronson; Amer A Beg; Audrey Minden
Journal: Mol Cell Biol Date: 2003-10 Impact factor: 4.272

3. Rac deletion in osteoclasts causes severe osteopetrosis.

Authors: Monica Croke; F Patrick Ross; Matti Korhonen; David A Williams; Wei Zou; Steven L Teitelbaum
Journal: J Cell Sci Date: 2011-11-23 Impact factor: 5.285

Review 4. Application of in utero electroporation and live imaging in the analyses of neuronal migration during mouse brain development.

Authors: Yoshiaki V Nishimura; Tomoyasu Shinoda; Yutaka Inaguma; Hidenori Ito; Koh-Ichi Nagata
Journal: Med Mol Morphol Date: 2012-03-20 Impact factor: 2.309

10. Phosphorylation of Rac1 T108 by extracellular signal-regulated kinase in response to epidermal growth factor: a novel mechanism to regulate Rac1 function.

Authors: Junfeng Tong; Laiji Li; Barbara Ballermann; Zhixiang Wang
Journal: Mol Cell Biol Date: 2013-09-16 Impact factor: 4.272

Rac1 is required for the formation of three germ layers during gastrulation.

Review 1. Regulatory and signaling properties of the Vav family.

2. PAK4 kinase is essential for embryonic viability and for proper neuronal development.

3. Rac deletion in osteoclasts causes severe osteopetrosis.

Review 4. Application of in utero electroporation and live imaging in the analyses of neuronal migration during mouse brain development.

5. Rac1 is essential for basement membrane-dependent epiblast survival.

6. Critical roles for Rac GTPases in T-cell migration to and within lymph nodes.

Review 7. Cellular and molecular mechanisms underlying blood vessel lumen formation.

8. Diffuse angiopathy in Adams-Oliver syndrome associated with truncating DOCK6 mutations.

9. Requirement of Rac1 in the development of cardiac hypertrophy.

10. Phosphorylation of Rac1 T108 by extracellular signal-regulated kinase in response to epidermal growth factor: a novel mechanism to regulate Rac1 function.