Literature DB >> 20625591

Highly efficient chemoenzymatic synthesis of beta1-4-linked galactosides with promiscuous bacterial beta1-4-galactosyltransferases.

Kam Lau1, Vireak Thon, Hai Yu, Li Ding, Yi Chen, Musleh M Muthana, Denton Wong, Ronald Huang, Xi Chen.   

Abstract

Two bacterial beta1-4-galactosyltransferases, NmLgtB and Hp1-4GalT, exhibit promiscuous and complementary acceptor substrate specificity. They have been used in an efficient one-pot multienzyme system to synthesize LacNAc, lactose, and their derivatives including those containing negatively charged 6-O-sulfated GlcNAc and C2-substituted GlcNAc or Glc, from monosaccharide derivatives and inexpensive Glc-1-P.

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Year:  2010        PMID： 20625591      PMCID： PMC3114949          DOI： 10.1039/c0cc01381a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  38 in total

1.  Sugar nucleotide regeneration beads (superbeads): a versatile tool for the practical synthesis of oligosaccharides.

Authors:  X Chen; J Fang; J Zhang; Z Liu; J Shao; P Kowal; P Andreana; P G Wang
Journal:  J Am Chem Soc       Date:  2001-03-07       Impact factor: 15.419

Review 2.  Carbohydrate-modifying sulfotransferases: structure, function, and pathophysiology.

Authors:  M Fukuda; N Hiraoka; T O Akama; M N Fukuda
Journal:  J Biol Chem       Date:  2001-10-03       Impact factor: 5.157

3.  Production of alpha-galactosyl epitopes via combined use of two recombinant whole cells harboring UDP-galactose 4-epimerase and alpha-1,3-galactosyltransferase.

Authors:  X Chen; W Zhang; J Wang; J Fang; P G Wang
Journal:  Biotechnol Prog       Date:  2000 Jul-Aug

4.  Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase.

Authors:  T Torii; M Fukuta; O Habuchi
Journal:  Glycobiology       Date:  2000-02       Impact factor: 4.313

5.  Structure-based design of beta 1,4-galactosyltransferase I (beta 4Gal-T1) with equally efficient N-acetylgalactosaminyltransferase activity: point mutation broadens beta 4Gal-T1 donor specificity.

Authors:  Boopathy Ramakrishnan; Pradman K Qasba
Journal:  J Biol Chem       Date:  2002-03-26       Impact factor: 5.157

Review 6.  Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

Authors:  M Amado; R Almeida; T Schwientek; H Clausen
Journal:  Biochim Biophys Acta       Date:  1999-12-06

7.  Functional genomics of Helicobacter pylori: identification of a beta-1,4 galactosyltransferase and generation of mutants with altered lipopolysaccharide.

Authors:  S M Logan; J W Conlan; M A Monteiro; W W Wakarchuk; E Altman
Journal:  Mol Microbiol       Date:  2000-03       Impact factor: 3.501

8.  Cloning and expression of beta1,4-galactosyltransferase gene from Helicobacter pylori.

Authors:  T Endo; S Koizumi; K Tabata; A Ozaki
Journal:  Glycobiology       Date:  2000-08       Impact factor: 4.313

Review 9.  Keratan sulfate: structure, biosynthesis, and function.

Authors:  J L Funderburgh
Journal:  Glycobiology       Date:  2000-10       Impact factor: 4.313

10.  Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid.

Authors:  Hongzhi Cao; Saddam Muthana; Yanhong Li; Jiansong Cheng; Xi Chen
Journal:  Bioorg Med Chem Lett       Date:  2009-08-26       Impact factor: 2.823
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  47 in total

1.  Chemoenzymatic synthesis of sialosides containing C7-modified sialic acids and their application in sialidase substrate specificity studies.

Authors:  Zahra Khedri; Yanhong Li; Saddam Muthana; Musleh M Muthana; Ching-Wen Hsiao; Hai Yu; Xi Chen
Journal:  Carbohydr Res       Date:  2014-03-06       Impact factor: 2.104

2.  Fluorescent labeling agents change binding profiles of glycan-binding proteins.

Authors:  Yiyan Fei; Yung-Shin Sun; Yanhong Li; Kam Lau; Hai Yu; Harshal A Chokhawala; Shengshu Huang; James P Landry; Xi Chen; Xiangdong Zhu
Journal:  Mol Biosyst       Date:  2011-10-18

3.  Biochemical characterization of Helicobacter pylori α1-3-fucosyltransferase and its application in the synthesis of fucosylated human milk oligosaccharides.

Authors:  Jing Bai; Zhigang Wu; Go Sugiarto; Madhusudhan Reddy Gadi; Hai Yu; Yanhong Li; Cong Xiao; Alice Ngo; Baohua Zhao; Xi Chen; Wanyi Guan
Journal:  Carbohydr Res       Date:  2019-05-16       Impact factor: 2.104

4.  The one-pot multienzyme (OPME) synthesis of human blood group H antigens and a human milk oligosaccharide (HMOS) with highly active Thermosynechococcus elongates α1-2-fucosyltransferase.

Authors:  Chao Zhao; Yijing Wu; Hai Yu; Ishita M Shah; Yanhong Li; Jie Zeng; Bin Liu; David A Mills; Xi Chen
Journal:  Chem Commun (Camb)       Date:  2016-02-11       Impact factor: 6.222

5.  Targeting Base Excision Repair Glycosylases with DNA Containing Transition State Mimics Prepared via Click Chemistry.

Authors:  Philip K Yuen; Sydnee A Green; Jonathan Ashby; Kori T Lay; Abhishek Santra; Xi Chen; Martin P Horvath; Sheila S David
Journal:  ACS Chem Biol       Date:  2019-01-02       Impact factor: 5.100

6.  Facile Chemoenzymatic Synthesis of O-Mannosyl Glycans.

Authors:  Shuaishuai Wang; Qing Zhang; CongCong Chen; Yuxi Guo; Madhusudhan Reddy Gadi; Jin Yu; Ulrika Westerlind; Yunpeng Liu; Xuefeng Cao; Peng G Wang; Lei Li
Journal:  Angew Chem Int Ed Engl       Date:  2018-05-18       Impact factor: 15.336

7.  Chemoenzymatic Assembly of Mammalian O-Mannose Glycans.

Authors:  Caicai Meng; Aniruddha Sasmal; Yan Zhang; Tian Gao; Chang-Cheng Liu; Naazneen Khan; Ajit Varki; Fengshan Wang; Hongzhi Cao
Journal:  Angew Chem Int Ed Engl       Date:  2018-06-25       Impact factor: 15.336

8.  New Means to Control Molecular Assembly.

Authors:  Jiali Zhang; Hai Yu; Bradley Harris; Yunbo Zheng; Umit Celik; Lan Na; Roland Faller; Xi Chen; Dominik R Haudenschild; Gang-Yu Liu
Journal:  J Phys Chem C Nanomater Interfaces       Date:  2020-02-23       Impact factor: 4.126

9.  Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis.

Authors:  Hai Yu; Kam Lau; Vireak Thon; Chloe A Autran; Evelyn Jantscher-Krenn; Mengyang Xue; Yanhong Li; Go Sugiarto; Jingyao Qu; Shengmao Mu; Li Ding; Lars Bode; Xi Chen
Journal:  Angew Chem Int Ed Engl       Date:  2014-05-21       Impact factor: 15.336

10.  Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes.

Authors:  Zhigang Wu; Yunpeng Liu; Cheng Ma; Lei Li; Jing Bai; Lauren Byrd-Leotis; Yi Lasanajak; Yuxi Guo; Liuqing Wen; He Zhu; Jing Song; Yanhong Li; David A Steinhauer; David F Smith; Baohua Zhao; Xi Chen; Wanyi Guan; Peng George Wang
Journal:  Org Biomol Chem       Date:  2016-11-29       Impact factor: 3.876
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