Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis.

Literature DB >> 24848971

Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis.

Hai Yu¹, Kam Lau, Vireak Thon, Chloe A Autran, Evelyn Jantscher-Krenn, Mengyang Xue, Yanhong Li, Go Sugiarto, Jingyao Qu, Shengmao Mu, Li Ding, Lars Bode, Xi Chen.

Abstract

Two novel synthetic α2-6-linked disialyl hexasaccharides, disialyllacto-N-neotetraose (DSLNnT) and α2-6-linked disialyllacto-N-tetraose (DS'LNT), were readily obtained by highly efficient one-pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize the desired complex oligosaccharides with high efficiency and selectivity. DSLNnT and DS'LNT were shown to protect neonatal rats from necrotizing enterocolitis (NEC) and are good therapeutic candidates for preclinical experiments and clinical application in treating NEC in preterm infants.

Entities: Chemical Disease Gene Mutation Species

Keywords: disialyl glycans; enzymatic synthesis; enzymes; necrotizing enterocolitis; oligosaccharides

Mesh：

Substances：

Year: 2014 PMID： 24848971 PMCID： PMC4147952 DOI： 10.1002/anie.201403588

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

34 in total

1. Recent advances in o-sialylation.

Authors: G J Boons; A V Demchenko
Journal: Chem Rev Date: 2000-12-13 Impact factor: 60.622

2. Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP).

Authors: Musleh M Muthana; Jingyao Qu; Yanhong Li; Lei Zhang; Hai Yu; Li Ding; Hamed Malekan; Xi Chen
Journal: Chem Commun (Camb) Date: 2012-02-03 Impact factor: 6.222

3. A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries.

Authors: Hai Yu; Harshal Chokhawala; Rebekah Karpel; Hui Yu; Bingyuan Wu; Jianbo Zhang; Yingxin Zhang; Qiang Jia; Xi Chen
Journal: J Am Chem Soc Date: 2005-12-21 Impact factor: 15.419

4. Structural determination and daily variations of porcine milk oligosaccharides.

Authors: Nannan Tao; Karen L Ochonicky; J Bruce German; Sharon M Donovan; Carlito B Lebrilla
Journal: J Agric Food Chem Date: 2010-04-28 Impact factor: 5.279

5. Assignment of the 1H- and 13C-NMR spectra of eight oligosaccharides of the lacto-N-tetraose and neotetraose series.

Authors: G Strecker; J M Wieruszeski; J C Michalski; J Montreuil
Journal: Glycoconj J Date: 1989 Impact factor: 2.916

Review 6. Human milk oligosaccharides: every baby needs a sugar mama.

Authors: Lars Bode
Journal: Glycobiology Date: 2012-04-18 Impact factor: 4.313

7. Biosynthesis of disialylated beta-D-galactopyranosyl-(1----3)-2-acetamido-2-deoxy-beta-D-glucopy ran osyl oligosaccharide chains. Identification of a beta-D-galactoside alpha-(2----3)- and a 2-acetamido-2-deoxy-beta-D-glucoside alpha-(2----6)-sialyltransferase in regenerating rat liver and other tissues.

Authors: H T de Heij; P L Koppen; D H van den Eijnden
Journal: Carbohydr Res Date: 1986-06-01 Impact factor: 2.104

8. Reassembled biosynthetic pathway for large-scale carbohydrate synthesis: alpha-Gal epitope producing "superbug".

Authors: Xi Chen; Ziye Liu; Jianbo Zhang; Wei Zhang; Przemyslaw Kowal; Peng George Wang
Journal: Chembiochem Date: 2002-01-04 Impact factor: 3.164

Review 9. Milk oligosaccharides and metabolism in infants.

Authors: Silvia Rudloff; Clemens Kunz
Journal: Adv Nutr Date: 2012-05-01 Impact factor: 8.701

10. Substrate promiscuity of N-acetylhexosamine 1-kinases.

Authors: Yanhong Li; Hai Yu; Yi Chen; Kam Lau; Li Cai; Hongzhi Cao; Vinod Kumar Tiwari; Jingyao Qu; Vireak Thon; Peng George Wang; Xi Chen
Journal: Molecules Date: 2011-07-28 Impact factor: 4.411

26 in total

Review 1. Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant.

Authors: Kannikar Vongbhavit; Mark A Underwood
Journal: Clin Ther Date: 2016-02-09 Impact factor: 3.393

Review 10. Enteral Feeding Interventions in the Prevention of Necrotizing Enterocolitis: A Systematic Review of Experimental and Clinical Studies.

Authors: Ilse H de Lange; Charlotte van Gorp; Laurens D Eeftinck Schattenkerk; Wim G van Gemert; Joep P M Derikx; Tim G A M Wolfs
Journal: Nutrients Date: 2021-05-19 Impact factor: 5.717

Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis.

1. Recent advances in o-sialylation.

2. Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP).

3. A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries.

4. Structural determination and daily variations of porcine milk oligosaccharides.

5. Assignment of the 1H- and 13C-NMR spectra of eight oligosaccharides of the lacto-N-tetraose and neotetraose series.

Review 6. Human milk oligosaccharides: every baby needs a sugar mama.

8. Reassembled biosynthetic pathway for large-scale carbohydrate synthesis: alpha-Gal epitope producing "superbug".

Review 9. Milk oligosaccharides and metabolism in infants.

10. Substrate promiscuity of N-acetylhexosamine 1-kinases.

Review 1. Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant.

2. Facile Enzymatic Synthesis of Ketoses.

3. Synthesis of asymmetrical multiantennary human milk oligosaccharides.

4. Synthesis of lacto-N-tetraose.

Review 5. Oligosaccharide Synthesis and Translational Innovation.

6. Sequential One-Pot Multienzyme Chemoenzymatic Synthesis of Glycosphingolipid Glycans.

Review 7. The Human Milk Glycome as a Defense Against Infectious Diseases: Rationale, Challenges, and Opportunities.

8. Enzymatic and Chemoenzymatic Syntheses of Disialyl Glycans and Their Necrotizing Enterocolitis Preventing Effects.

9. Redox-Controlled Site-Specific α2-6-Sialylation.

Review 10. Enteral Feeding Interventions in the Prevention of Necrotizing Enterocolitis: A Systematic Review of Experimental and Clinical Studies.