Literature DB >> 26864394

The one-pot multienzyme (OPME) synthesis of human blood group H antigens and a human milk oligosaccharide (HMOS) with highly active Thermosynechococcus elongates α1-2-fucosyltransferase.

Chao Zhao1, Yijing Wu, Hai Yu, Ishita M Shah, Yanhong Li, Jie Zeng, Bin Liu, David A Mills, Xi Chen.   

Abstract

A novel α1-2-fucosyltransferase from Thermosynechococcus elongatus BP-1 (Te2FT) with high fucosyltransferase activity and low donor hydrolysis activity was discovered and characterized. It was used in an efficient one-pot multienzyme (OPME) fucosylation system for the high-yield synthesis of human blood group H antigens containing β1-3-linked galactosides and an important human milk oligosaccharide (HMOS) lacto-N-fucopentaose I (LNFP I) on preparative and gram scales. LNFP I was shown to be selectively consumed by Bifidobacterium longum subsp. infantis but not Bifidobacterium animalis subsp. lactis and is a potential prebiotic.

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Year:  2016        PMID： 26864394      PMCID： PMC4775349          DOI： 10.1039/c5cc10646j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  39 in total

1.  A comparison of two probiotic strains of bifidobacteria in premature infants.

Authors:  Mark A Underwood; Karen M Kalanetra; Nicholas A Bokulich; Zachery T Lewis; Majid Mirmiran; Daniel J Tancredi; David A Mills
Journal:  J Pediatr       Date:  2013-08-29       Impact factor: 4.406

2.  Escherichia coli O86 O-antigen biosynthetic gene cluster and stepwise enzymatic synthesis of human blood group B antigen tetrasaccharide.

Authors:  Wen Yi; Jun Shao; Lizhi Zhu; Mei Li; Mamata Singh; Yuquan Lu; Steven Lin; Hanfen Li; Kang Ryu; Jie Shen; Hongjie Guo; Qingjia Yao; C Allen Bush; Peng G Wang
Journal:  J Am Chem Soc       Date:  2005-02-23       Impact factor: 15.419

Review 3.  Breast milk oligosaccharides: structure-function relationships in the neonate.

Authors:  Jennifer T Smilowitz; Carlito B Lebrilla; David A Mills; J Bruce German; Samara L Freeman
Journal:  Annu Rev Nutr       Date:  2014-05-15       Impact factor: 11.848

4.  Annotation and structural elucidation of bovine milk oligosaccharides and determination of novel fucosylated structures.

Authors:  Danielle L Aldredge; Maria R Geronimo; Serenus Hua; Charles C Nwosu; Carlito B Lebrilla; Daniela Barile
Journal:  Glycobiology       Date:  2013-02-22       Impact factor: 4.313

5.  Structural determination and daily variations of porcine milk oligosaccharides.

Authors:  Nannan Tao; Karen L Ochonicky; J Bruce German; Sharon M Donovan; Carlito B Lebrilla
Journal:  J Agric Food Chem       Date:  2010-04-28       Impact factor: 5.279

Review 6.  Enzymatic synthesis of lacto-N-difucohexaose I which binds to Helicobacter pylori.

Authors:  Tatsuo Miyazaki; Takeshi Sato; Kiyoshi Furukawa; Katsumi Ajisaka
Journal:  Methods Enzymol       Date:  2010       Impact factor: 1.600

7.  Sequence of Escherichia coli O128 antigen biosynthesis cluster and functional identification of an alpha-1,2-fucosyltransferase.

Authors:  Jun Shao; Mei Li; Qiang Jia; Yuquan Lu; Peng George Wang
Journal:  FEBS Lett       Date:  2003-10-09       Impact factor: 4.124

8.  Stool microbiota and vaccine responses of infants.

Authors:  M Nazmul Huda; Zachery Lewis; Karen M Kalanetra; Mamunur Rashid; Shaikh M Ahmad; Rubhana Raqib; Firdausi Qadri; Mark A Underwood; David A Mills; Charles B Stephensen
Journal:  Pediatrics       Date:  2014-07-07       Impact factor: 7.124

9.  A sialyltransferase mutant with decreased donor hydrolysis and reduced sialidase activities for directly sialylating LewisX.

Authors:  Go Sugiarto; Kam Lau; Jingyao Qu; Yanhong Li; Sunghyuk Lim; Shengmao Mu; James B Ames; Andrew J Fisher; Xi Chen
Journal:  ACS Chem Biol       Date:  2012-05-14       Impact factor: 5.100

10.  WbgL: a novel bacterial α1,2-fucosyltransferase for the synthesis of 2'-fucosyllactose.

Authors:  Leonie Engels; Lothar Elling
Journal:  Glycobiology       Date:  2013-11-17       Impact factor: 4.313
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  12 in total

1.  Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens.

Authors:  Hai Yu; Abhishek Santra; Yanhong Li; John B McArthur; Tamashree Ghosh; Xiaoxiao Yang; Peng G Wang; Xi Chen
Journal:  Org Biomol Chem       Date:  2018-06-06       Impact factor: 3.876

2.  H. pylori α1-3/4-fucosyltransferase (Hp3/4FT)-catalyzed one-pot multienzyme (OPME) synthesis of Lewis antigens and human milk fucosides.

Authors:  Hai Yu; Yanhong Li; Zhigang Wu; Lei Li; Jie Zeng; Chao Zhao; Yijing Wu; Nova Tasnima; Jing Wang; Huaide Liu; Madhusudhan Reddy Gadi; Wanyi Guan; Peng G Wang; Xi Chen
Journal:  Chem Commun (Camb)       Date:  2017-10-05       Impact factor: 6.222

3.  One-pot multienzyme (OPME) chemoenzymatic synthesis of brain ganglioside glycans with human ST3GAL II expressed in E. coli.

Authors:  Xiaoxiao Yang; Hai Yu; Xiaohong Yang; Anoopjit Singh Kooner; Yue Yuan; Bryant Luu; Xi Chen
Journal:  ChemCatChem       Date:  2021-11-29       Impact factor: 5.497

4.  HPLC-Based Automated Synthesis of Glycans in Solution.

Authors:  Samira Escopy; Yashapal Singh; Keith J Stine; Alexei V Demchenko
Journal:  Chemistry       Date:  2022-05-25       Impact factor: 5.020

5.  Fucosylated Human Milk Oligosaccharide Foraging within the Species Bifidobacterium pseudocatenulatum Is Driven by Glycosyl Hydrolase Content and Specificity.

Authors:  Guy Shani; Jennifer L Hoeflinger; Britta E Heiss; Chad F Masarweh; Jules A Larke; Nick M Jensen; Saumya Wickramasinghe; Jasmine C Davis; Elisha Goonatilleke; Amr El-Hawiet; Linh Nguyen; John S Klassen; Carolyn M Slupsky; Carlito B Lebrilla; David A Mills
Journal:  Appl Environ Microbiol       Date:  2021-11-10       Impact factor: 5.005

6.  Biosynthesis of Raffinose and Stachyose from Sucrose via an In Vitro Multienzyme System.

Authors:  Chaoyu Tian; Jiangang Yang; Yan Zeng; Tong Zhang; Yingbiao Zhou; Yan Men; Chun You; Yueming Zhu; Yuanxia Sun
Journal:  Appl Environ Microbiol       Date:  2019-01-09       Impact factor: 4.792

7.  Substrate and Process Engineering for Biocatalytic Synthesis and Facile Purification of Human Milk Oligosaccharides.

Authors:  Yuanyuan Bai; Xiaohong Yang; Hai Yu; Xi Chen
Journal:  ChemSusChem       Date:  2022-02-18       Impact factor: 9.140

8.  Enzyme activity and phosphate uptake in the small intestine of Sprague Dawley rats improved by supplementation of infant formula with prebiotics.

Authors:  Shuiyue Zhou; Yuanxin Hang; Jianwu Wang; Rejun Fang
Journal:  Anim Nutr       Date:  2018-07-10

9.  Treponema primitia α1-2-fucosyltransferase-catalyzed one-pot multienzyme synthesis of fucosylated oligosaccharide lacto-N-fucopentaose I with antiviral activity against enterovirus 71.

Authors:  Yuanyuan Liu; Aijun Tong; Xiaoxiang Gao; Sinan Yuan; Ruting Zhong; Chao Zhao
Journal:  Food Chem X       Date:  2022-02-26

Review 10.  Leloir Glycosyltransferases in Applied Biocatalysis: A Multidisciplinary Approach.

Authors:  Luuk Mestrom; Marta Przypis; Daria Kowalczykiewicz; André Pollender; Antje Kumpf; Stefan R Marsden; Isabel Bento; Andrzej B Jarzębski; Katarzyna Szymańska; Arkadiusz Chruściel; Dirk Tischler; Rob Schoevaart; Ulf Hanefeld; Peter-Leon Hagedoorn
Journal:  Int J Mol Sci       Date:  2019-10-23       Impact factor: 5.923
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