BACKGROUND: GFR estimation is of major importance in everyday clinical practice. Usually it is done using one of the many eGFR equations available. In this study we compared in our population four widespread eGFR equations and our own empirical eGFR, with creatinine clearance calculated through a timed urine collection. PATIENTS AND METHODS: We collected laboratory data of 907 patients from our clinic and outpatient department through a ten-year period and statistically compared the eGFR results between them and with the timed urine collection creatinine clearances. RESULTS: All eGFR equations gave acceptable approximations to the timed urine collection creatinine clearances. However, in different subpopulations some equations did better than others, without any clear advantage of any equation overall. Surprisingly, our empirical equation named DAF also gave acceptable approximations regardless of age, weight and sex of the patient. CONCLUSIONS: In our population our empirical eGFR method (DAF) gave satisfactory results regarding the monitoring of renal function, compared with four other eGFR methods. We suggest that it could provide a very fast and easy to use means of eGFR calculation.
BACKGROUND: GFR estimation is of major importance in everyday clinical practice. Usually it is done using one of the many eGFR equations available. In this study we compared in our population four widespread eGFR equations and our own empirical eGFR, with creatinine clearance calculated through a timed urine collection. PATIENTS AND METHODS: We collected laboratory data of 907 patients from our clinic and outpatient department through a ten-year period and statistically compared the eGFR results between them and with the timed urine collection creatinine clearances. RESULTS: All eGFR equations gave acceptable approximations to the timed urine collection creatinine clearances. However, in different subpopulations some equations did better than others, without any clear advantage of any equation overall. Surprisingly, our empirical equation named DAF also gave acceptable approximations regardless of age, weight and sex of the patient. CONCLUSIONS: In our population our empirical eGFR method (DAF) gave satisfactory results regarding the monitoring of renal function, compared with four other eGFR methods. We suggest that it could provide a very fast and easy to use means of eGFR calculation.
Authors: Raghuveer Halkar; Andrew Taylor; Amita Manatunga; Muta M Issa; Samuel E Myrick; Sandra Grant; Neeta V Shenvi Journal: Urology Date: 2007-03 Impact factor: 2.649
Authors: Edmund J Lamb; Michelle C Webb; David E Simpson; Anthony J Coakley; David J Newman; Shelagh E O'Riordan Journal: J Am Geriatr Soc Date: 2003-07 Impact factor: 5.562
Authors: Salmaan Kanji; Meghan Hayes; Adam Ling; Larissa Shamseer; Clarence Chant; David J Edwards; Scott Edwards; Mary H H Ensom; David R Foster; Brian Hardy; Tyree H Kiser; Charles la Porte; Jason A Roberts; Rob Shulman; Scott Walker; Sheryl Zelenitsky; David Moher Journal: Clin Pharmacokinet Date: 2015-07 Impact factor: 6.447
Authors: Elizabeth J Samelson; Paul D Miller; Claus Christiansen; Nadia S Daizadeh; Luanda Grazette; Mary S Anthony; Ogo Egbuna; Andrea Wang; Suresh R Siddhanti; Angela M Cheung; Nathalie Franchimont; Douglas P Kiel Journal: J Bone Miner Res Date: 2014-02 Impact factor: 6.741